103例新生儿尸检病例临床与病理诊断对比

目的探讨新生儿尸检病例临床与病理诊断的相关问题。方法对103例新生儿尸检病例的临床诊断与病理诊断进行对比,统计临床诊断符合率,对导致死亡的前四位疾病进行临床诊断的敏感度、特异度和约登指数统计。结果103例中临床与病理诊断符合率81.6%。引起死亡的前四位疾病依次为肺出血、肺透明膜病、肺炎及颅内出血。这四种疾病的约登指数分别为0.74,0.89,0.79和0.78。10例先天性畸形均为多发性致死性畸形。结论引起新生儿死亡的常见疾病是肺出血、肺透明膜病、肺炎及颅内出血,其次为先天性畸形。开展尸体解剖能使一些疑难病例得以明确诊断,有助于临床医师提高诊断水平。

The comparison between clinical and pathological diagnosis in 103 dead neonatal cases

Objective To explore the relationship of clinical and pathological diagnosis in dissected neonatal cases.Methods The clinical diagnosis was compared with pathological diagnosis in 103 dissected neonatal cases.The diagnostic coincidence rate were counted.The sensitivity,specificity and Youden's index of the first four diseases causing death were counted.Results The diagnostic coincidence rate between the clinic and the pathology was 81.6%.The first four diseases causing death in 103 cases were pulmonary hemorrhage,hyaline membrane disease,pneumonia and intracranial hemorrhage.Youden's index of them were individually 0.74,0.89,0.79 and 0.78.10 cases of congenital deformity were all the multiple deformity causing death.Conclusion The common diseases causing death in newborn are pulmonary hemorrhage,hyaline membrane disease,pneumonia and intracranial hemorrhage,It is secondly congenital deformity.Autopsy is a useful tool for recognizing real diagnosis.