穴位贴敷理疗仪对原发性失眠患者脑神经递质的影响

目的通过脑电超慢涨落图(ET)作为客观评价指标进行监测和疗效对比,验证穴位贴敷理疗仪治疗原发性失眠的临床疗效。方法将72例原发性失眠患者随机分为对照组和治疗组,各36例。其中对照组脱落4例;治疗组脱落3例。实际入组对照组32例,治疗组33例。对照组:口服安神补脑液,早餐前服用1支,晚餐后服用1支,每日2支。治疗组:采用穴位贴敷理疗仪治疗,每天治疗1次,连续治疗5 d,休息2 d,疗程:3个疗程,5 d为1个疗程。2组均治疗结束2周后随访。结果对照组总有效率为68.75%,治疗组总有效率为87.88%,2组有效率比较无统计学意义。2组治疗后GABA、Glu、5-HT、Ach、NE、DA比较,有统计学意义(P<0.05)结论根据统计学的差异性分析可知,治疗组与对照组对原发性失眠均有治疗效果,治疗组在调节原发性失眠患者脑内GABA、5-HT、Ach上升;Glu、NE、DA下降方面优于对照组,但在改善Ach上升方面并不明显,总体疗效方面治疗组的临床治疗效果更显著。

Effect of acupoint application physiotherapy instrument on brain neurotransmitters in patients with primary insomnia

Objective To monitor,compare and ultimately to verify the clinical curative effect of acupoint application physiotherapy instrument in the treatment of primary insomnia,with electroencephalogram(ET)as an objective evaluation index.Methods 72 patients with insomnia were divided into control group and treatment group in accordance with strict screening and inclusion criteria.Among the subjects,32 patients were left in the drug group after 4 cases dropped out and 33 patients were left in the instrument group with 3 cases of withdrawing.Patients in the drug group were given Anshen Bunao Liquid orally,1 before breakfast and 1 after dinner,while patients in the instrument group were treated with acupoint application physiotherapy instrument once a day,with a rest for 2 days after a continuous treatment for 5 days.Both groups received treatment for 3 courses,with 5 days as a course and were followed up 2 weeks later after treatment.Results 65 patients with primary insomnia completed the treatment in this study,with the total eff ective rate of 68.75%in the control group(32 cases)and 87.88%in the treatment group(33 cases).There was no signifi cant diff erence in the eff ective rate between the two groups byχ² test(χ²=3.518,P=0.061>0.05).Conclusion According to the statistical diff erence analysis,both the treatment group and the control group have therapeutic eff ect on primary insomnia.The treatment group is superior to the control group in regulating the increase of GABA,5-HT,ACh and the decrease of Glu,NE and DA in the brain of patients with primary insomnia,but it is not obvious in improving the increase of ACh.The overall clinical eff ect of the treatment group is more signifi cant.