微球给药系统的工艺优化研究

目的 :阐述微球制备工艺中的优化技术。方法 :检索近年来国内外文献并进行整理和归纳。结果 :单因素设计、正交设计、均匀设计、因子设计是目前微球工艺中常用的优化方法。结论 :通过上述方法优化微球的制备工艺 ,可在一定条件下达到经济、高效的目的 ,更理想的优化技术尚有待研究

Optimization of the preparation of microsphere drug delivery system

OBJECTIVE:To illustrate the optimized technique applied to microspheres preparation.METHOD:Recent literature were looked up,collated and summarized.RESULTS:Single factor design,orthogonal design,uniform design and factorial design are widely used for the optimization purpose.CONCLUSION:The formulation procedure of mocrospheres will be established efficiently by the experimental design methods,but further studies seems to be needed.