血清炎性因子在难治性肺炎支原体肺炎患儿中变化的临床意义

目的探究血清炎性因子在难治性肺炎支原体肺炎（RMPP）患儿中的变化规律及临床意义。方法将该院收治的40例肺炎支原体肺炎（MPP）患儿，按照临床特征分为RMPP组19例与普通MPP组21例，同时选取21例健康体检儿童作为对照组，对三组研究对象的血清炎性因子进行检测并对比，比较RMPP组与普通MPP组入院时与治疗后血清炎性因子的变化。结果三组的血清炎性因子IL-4、IL-5、IL-10、IFN-γ等对比，差异均具有统计学意义，且RMPP组的IL-4、IL-10显著高于普通MPP组；RMPP组治疗后的IL-10显著低于入院时。结论RMPP病情的发生及发展与IL-4、IL-5、IL-10、IFN-γ等变化有关，IL-4、IL-10等可作为判别RMPP的指标，而IL-10可作为评估RMPP的疗效指标。

Clinical significance of changes of serum inflammatory factors in children with RMPP

Objective To investigate the changes and clinical significance of serum inflammatory factors in children with refractory mycoplasma pneumoniae pneumonia （RMPP）. Methods A total of 40 children with MPP were assigned into RMPP group （n = 19） and general MPP group（ n = 21 ） according to the clinical features, and 21 healthy children were chosen as control group. Serum inflammatory factors of three groups were detected, and changes of serum inflammatory factors in RMPP group and general MPP group at admission and after the treatment were analyzed. Results The differences in Serum inflammatory cytokines IL4, IL-6, IL-10, and IFN-3,among three groups were statistically significant, and IL4, IL-10 of RMPP group were significantly higher than those of general MPP group. IL- l0 of RMPP group after the treatment was significantly lower than that at admission. Conclusions The attack and development of RM- PP may be associated with the changes of IL4, IL-6, IL-10 and IFN-T. IL4 and IL-10 can be index for diagnosing RMPP, and IL-10 may be efficacy index of RMPP.