VEGFR酪氨酸激酶抑制剂的临床应用与研究进展

血管内皮生长因子（ VEGF ）可诱导肿瘤的血管新生，在肿瘤生长中起到了关键作用。抑制血管内皮生长因子受体（ VEGFR）酪氨酸激酶能在一定程度上抑制肿瘤的生长， VEGFR酪氨酸激酶抑制剂已成为现在研究的热点之一。该文对VEGF和VEGFR进行了简要介绍，并简述了VEGFR酪氨酸激酶抑制剂的临床应用和主要化学结构类型。

Clinical use and research of VEGFR inhibitor

Vascular endothelial growth factor （VEGF） can induce angiogenesis in tumor,which has played a key role in inhibiting VEGFR tyrosine kinase. To some extent,it can inhibit tumor growth. So VEGFR tyrosine kinase has become one of the research hotspot now. This paper makes a brief introduction to VEGF and VEGFR. In addition,the clinical application and the main chemical structure type of VEGFR tyrosine kinase inhibitors are briefly introduced.