| 制剂辅料对注射用葛根素溶血的影响 |
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| 引用本文： | 蔡海峰,丁选胜.制剂辅料对注射用葛根素溶血的影响[J].安徽医药,2014,0(11):2040-2043. |
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| 作者姓名： | 蔡海峰 丁选胜 |
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| 作者单位： | 蔡海峰 (中国药科大学临床药学教研室,江苏 南京,210009)； 丁选胜 (中国药科大学临床药学教研室,江苏 南京,210009)； |
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| 基金项目： | 国家自然科学基金资助项目(项目编号：81073145) |
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| 摘 要： | 目的：探讨制剂辅料对注射用葛根素体外溶血的影响，为临床安全用药提供依据。方法采用改良体外试管法评价注射用葛根素及其制剂辅料对家兔红细胞的溶血作用。结果注射用葛根素可引起家兔红细胞溶血，甘露醇和碳酸氢钠混合液也可以引起家兔红细胞溶血。结论葛根素以及甘露醇和碳酸氢钠之间交互作用可能是引起注射用葛根素溶血的主要原因。
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| 关 键 词： | 注射用葛根素 甘露醇 碳酸氢钠 体外溶血 |
Hemolytic effects of puerarin for injection by excipients |
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| CAI Hai-feng,DING Xuan-sheng.Hemolytic effects of puerarin for injection by excipients[J].Anhui Medical and Pharmaceutical Journal,2014,0(11):2040-2043. |
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| Authors: | CAI Hai-feng DING Xuan-sheng |
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| Institution: | ( Department of Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 210009, China ) |
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| Abstract: | Objective To explore the excipients of puerarin for injection which can cause hemolysis of rabbit erythrocytes and to pro-vide reference for clinical safe drug use. Methods Improved test tube method was used in vitro to evaluate the hemolytic affection of injection component. Results The puerarin for injection could cause hemolysis of rabbit erythrocyte. And the mixture of mannitol and sodium bicarbonate had the same effect. Conclusions The puerarin and the interaction of excipients could be the main causes of he-molysis. |
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| Keywords: | puerarin for injection mannitol sodium bicarbonate in-vitro hemolysis |
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