| Abstract: | Background In clopidogrel-treated patients undergoing percutaneous coronary intervention(PCI),the effect of concomitant use of PPIs on prognosis remains unclear.Methods From July 2010 to June 2012,600patients after implantation of drug-eluting stent(DES)were assigned to 3 groups according to the medical therapy:group 1(n=200)received dural antiplatelet therapy(DAPT)alone(aspirine 100 mg daily plus clopidogrel 75 mg daily),group 2(n=199)received DAPT plus pantoprazole 20 mg daily while group 3(n=201)received DAPT plus omeprazole 20 mg daily for 1 year.The primary outcome was major adverse cardiovascular events(MACEs)which compose of death,nonfatal myocardial infarction(MI),nonfatal stroke,target vessel revascularization(TVR)or stent thrombosis(ST)at 1 year.Platelet reactivity was evaluated for all patients before PCI and 1 year after PCI.Results There was no significant difference in the platelet reactivity among the 3 groups at 1-year follow-up(27.3%versus 29.9%versus 29.3%,respectively,P=0.339).Neither was there significant difference in the incidence of 1-year MACEs(13%versus 14.6%versus 12.4%,respectively,P=0.809).Conclusions Concomitant use of pantoprazole or omeprazole did not influence platelet reactivity or clinical events in patients receiving DAPT after implantation of DES. |
