产吲哚金黄杆菌培养阳性患者的临床特点及耐药性分析

目的 分析本院送检标本培养出产吲哚金黄杆菌患者的临床特点及耐药情况。方法 采集2013年11月—2017年10月本院住院部所有标本培养出产吲哚金黄杆菌的患者49例的病历资料进行回顾性分析；采集2008年1月—2017年10月本院住院部所有产吲哚金黄杆菌培养阳性标本249例的药敏结果，选取非重复的122例进行耐药性分析。结果 49例患者均伴有严重基础疾病，送检前均使用过广谱抗生素，其中43例有侵入性操作，39例曾入住重症监护室(Intensive Care Unit, ICU)，仅复方磺胺甲噁唑(甲氧苄啶/磺胺甲噁唑)体外耐药率＜50%。结论 (1)本院分离的产吲哚金黄杆菌呈现多重耐药；(2)临床检出产吲哚金黄杆菌的患者多存在严重基础疾病、有广谱抗生素使用史、侵入性操作史、入住ICU史；(3)产吲哚金黄杆菌毒力较弱，本院常见定植。

Clinical features and antibiotic resistance analysis of Chryseobacterium indologenes

Objective To analyze the clinical features and antimicrobial resistance of Chryseobacterium indologenes. Methods We selected the clinical data of 49 Chryseobacterium indologenes isolates in our hospital from November 2013 to October 2017 for retrospective analysis. 122 non-repeated isolates of Chryseobacterium indologenes from January 2008 to October 2017 were collected for analysis of antimicrobial resistance. Results All of the 49 cases have been accompanied with severe underlying diseases and treated with broad-spectrum antibiotics. 43 cases have indwelling devices. 39 cases have been admitted to ICU. Only the resistance rate of Sulfamethoxazole/trimethoprim (SMZ/TMP) is less than 50%. Conclusion (1)Chryseobacterium indologenes isolated from our hospital is multi-drug resistant. (2) Most of the patients have severe basic diseases, recently use of broad-spectrum antibiotics, invasive procedures and hospitalization history in ICU. (3) The virulence of Chryseobacterium indologenes is low, and colonization is common in the