侵袭性纤维瘤病的非手术治疗

侵袭性纤维瘤病（aggressive fibromatosis，AF）是介于良恶性之间的交界性肿瘤，以局部浸润和高复发率为特点。AF的治疗既往以手术切除为主，但单纯手术复发率较高，盲目的手术往往造成患者机能或外形的损伤。近年来，包括内分泌治疗、手术、放疗、化疗、非甾体抗炎药物治疗、靶向药物、干扰素等多种治疗手段得到尝试，并取得一定疗效。此外，鉴于AF的惰性特征，观察等待也是多个行业指南推荐的一线方案。在AF的治疗决策上，必须综合考虑患者需求，注重机体功能和外形的保全，将非手术手段放到与手术同等地位加以考虑。

Non surgical Treatment of Aggressive Fibromatosis

Multiple modalities including endocrine therapy, surgery combined with radiotherapy, chemotherapy, non steroidal anti inflammatory drug treatment,targeted drugs, and interferon treatment have been tried and achieved comparable success in AF treatment. In addition, based on the indolent nature of AF, follow up observation is also recommended as first line treatment by several guidelines.For the treatment decision of AF,the patients’expectation must be considered. Function preservation and cosmetic requirement need to be emphasized,and non surgical treatment should be considered as important as surgery.