| 巨噬细胞在抗结核感染中的作用 |
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| 引用本文： | 王雅,李传友,王伟,唐神结. 巨噬细胞在抗结核感染中的作用[J]. 中国防痨杂志, 2018, 40(2): 218-221. DOI: 10.3969/j.issn.1000-6621.2018.02.020 |
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| 作者姓名： | 王雅 李传友 王伟 唐神结 |
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| 作者单位： | 101149.首都医科大学附属北京胸科医院 北京市结核病胸部肿瘤研究所 耐药结核病研究北京市重点实验室细菌免疫室(王雅、李传友、王伟),结核病多学科诊疗中心(唐神结)101149 首都医科大学附属北京胸科医院 北京市结核病胸部肿瘤研究所 耐药结核病研究北京市重点实验室细菌免疫室(王雅、李传友、王伟),结核病多学科诊疗中心(唐神结);101149.首都医科大学附属北京胸科医院 北京市结核病胸部肿瘤研究所 耐药结核病研究北京市重点实验室细菌免疫室(王雅、李传友、王伟),结核病多学科诊疗中心(唐神结) |
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| 基金项目： | 北京市医院管理局“登峰”计划专项(DFL20151501) |
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| 摘 要： | 巨噬细胞在结核病发病过程及机体抗结核免疫过程中扮演重要的角色。巨噬细胞是机体天然免疫的重要组成细胞,同时又是一类主要的抗原提呈细胞。在天然免疫和获得性免疫中都起着关键的作用。结核病是由结核分枝杆菌引起的严重危害人类健康的主要传染病,结核分枝杆菌可以通过多种途径来干扰机体巨噬细胞的免疫应答。本篇综述的目的在于讨论宿主被结核分枝杆菌入侵后,巨噬细胞在各种抗结核感染的免疫应答中的作用机制。
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| 关 键 词： | 巨噬细胞 分枝杆菌 结核 感染 免疫 综述 |
| 收稿时间： | 2017-05-31 |
The role of macrophages in anti-tuberculosis infection |
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| Ya WANG,Chuan-you LI,Wei WANG,Shen-jie TANG. The role of macrophages in anti-tuberculosis infection[J]. The Journal of The Chinese Antituberculosis Association, 2018, 40(2): 218-221. DOI: 10.3969/j.issn.1000-6621.2018.02.020 |
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| Authors: | Ya WANG Chuan-you LI Wei WANG Shen-jie TANG |
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| Affiliation: | Department of Bacteriology and Immunology, Beijing Key Laboratory for Drug Resistance Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China |
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| Abstract: | Macrophages play key roles in tuberculosis pathogenesis and host’s anti-tuberculosis immune defense. They represent an important component of innate immunity and are also major antigen presenting cells, functioning in both innate and acquired immunity. Tuberculosis, caused by Mycobacterium tuberculosis, is one of the main infectious diseases that are seriously harmful to human health. Mycobacterium tuberculosis can interfere with the immune response of macrophages in many ways. This review aims to elaborate the mechanisms of macrophages in various anti-tuberculosis immune responses after the infection of host by Mycobacterium tuberculosis. |
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| Keywords: | Macrophages Mycobacterium tuberculosis Infection Immunity Review |
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