绝经状态影响饮茶与乳腺癌患病风险关系的meta分析

目的：探讨绝经状态是否影响饮茶与乳腺癌患病风险之间的潜在关系。方法：以茶、茶多酚和乳腺癌为主题词联合检索Web of Science、PubMed、Medline、中国知网、维普、万方数据库1996年1月1日至2017年8月31日发表的相关文献。使用Stata 11.0软件进行效应值的合并和异质性检验，用NOS（New Castle Ottawa Scale）量表对每篇研究进行评分，通过Begg秩相关检验，Egger线性回归及剪补法计算发表偏倚。结果：本次研究共纳入9篇文献，通过比较茶饮品最高摄入量组和最低摄入量组乳腺癌的患病风险，结果初步表明饮茶对乳腺癌患病风险的影响无统计学意义（OR=1.01，95% CI：0.86~1.18），且绝经前（OR=0.92，95% CI：0.82~1.04）和绝经后（OR=1.11，95% CI：0.93~1.33）饮茶与乳腺癌患病的关联也无统计学意义（P < 0.05）。另外，在亚组分析中也未发现绝经状态会影响饮茶人群的乳腺癌患病风险。结论：饮茶与乳腺癌患病风险无关，且绝经状态不会影响饮茶人群的乳腺癌患病风险。但目前研究证据还比较有限。故在今后的研究中需开展大样本、多中心的队列或病例对照研究来进一步验证这一结论的准确性。

Menopausal status on risk for breast cancer from tea consumption: a meta-analysis

OBJECTIVE:To ascertain the potential relationship between tea consumption and risk of premenopausal and post-menopausal breast cancer. METHODS:Web of Science,PubMed,Medline,CNKI,VIP and WanFang database were independently searched from January 1st, 1996 to August 31st, 2017 by using "tea OR catechin OR tea polyphenol" AND "breast OR mammary" AND "cancer OR tumor OR carcinoma" as key words. The combination of the effect values and the heterogeneity test were performed using Stata 11.0 software. Each study was scored using the NOS (New Castle Ottawa Scale),and the publication bias was calculated using the funnel and Egger regression. RESULTS:A total of 9 studies (5 case-control studies;4 cohort studies) were included. The studies showed that tea intake was insignificantly associated with risk of breast cancer (OR=1.01,95% CI:0.86-1.18),the highest tea intake was also insignificant for risk of premenopausal (OR=0.92,95% CI:0.82-1.04) and postmenopausal breast cancers (OR=1.11,95% CI:0.93-1.33). In addition, we did not identify any statistically significant association between tea consumption and breast cancer risk in all the subgroup analyses (P < 0.05). CONCLUSION:In conclusion,our findings indicate that menopausal status had no effect on tea consumption and breast cancer risk. But the current evidence is still relatively limited. Therefore, large sample,multi-center cohort or case-control studies should be conducted to further clarify the accuracy of this conclusion.