Experimental renal papillary necrosis. Effects of beta adrenergic receptor blockade, heparin and hydrocortisone. |
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| Authors: | S K Bartsokas D G Papadimitriou C Koufos |
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| Affiliation: | 1. Institute of Pathologic Physiology, Athens University, Greece;2. Institute of Pathologic Anatomy, Athens University, Greece;1. Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA;2. Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA, USA;3. Center for Tissue Regeneration, Repair and Restoration, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA;1. Job Results Management Institute, 2544 Wakewood Hill Court Winston-Salem, NC 27106, U.S.A.;2. Sheldon B. Lubar School of Business, University of Wisconsin, 3202 N. Maryland Avenue Milwaukee, WI 53202, U.S.A.;1. Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China;2. The Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China;1. Johns Hopkins University School of Medicine, Baltimore, MD;2. New York University School of Medicine, New York, NY;3. Memorial Sloan-Kettering Cancer Center, Weill Cornell Medical College, New York, NY;4. University of Colorado School of Medicine, Denver, CO;5. Veterans Affairs Eastern Colorado Health Care System, Denver, CO;6. Indiana University School of Medicine, Indianapolis, IN;7. University of Nebraska Medical Center, Omaha, NE;8. Wayne State University School of Medicine, Detroit, MI;9. Cooper Medical School of Rowan University, Camden, NJ |
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| Abstract: | Renal papillary necrosis was induced in rats by daily subcutaneous injection of 15 mg 2-bromoethylamine hydrobromide (BEA) per 100 g of body weight for 2 successive days. This dose was 50% higher than that reported previously. Beta adrenergic receptor blockade with oxyprenolol did not influence the kidney damage.The administration of heparin did not show any effect. The doses applied did not induce the incoagulability for a sufficient period of time. On the contrary, treatment with hydrocortisone decreased papillary necrosis without inducing increased diuresis. |
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