| Affiliation: | (1) Department of Radiation Oncology, University Hospital Hamburg–Eppendorf, Hamburg, Germany;(2) Klinik für Strahlentherapie und Radioonkologie, Universitätskrankenhaus Hamburg–Eppendorf, Martinistraße 52, 20246 Hamburg, Germany |
| Abstract: | Background and Purpose: Analysis of treatment results of combined three–dimensional conformal radiotherapy (3DCRT) andhormonal therapy in patients with locally recurrent prostate cancer after radical prostatectomy.Patients and Methods: Between 1992 and 1998, 24 patients presented with a rising prostate–specific antigen (PSA) between 4and 152 months following radical prostatectomy and a local recurrence demonstrated by imaging. Recurrence was biopsy–provenin 13 cases. All patients were treated with 3DCRT to a total dose of 60–70 Gy. 21 patients (88%) received adjuvant hormonetherapy up to a maximum of 6 months.Results: All patients showed a response in PSA values after therapy. Median follow–up is 43 months. Overall survival is 80% and67% at 3 and 5 years, respectively. Biochemical control rates are 53% and 38% at 3 and 5 years, respectively. 14 patients developeda second PSA relapse. Acute and late toxicities, classified with the RTOG score, were moderate.Conclusion: Radiotherapy and short–term adjuvant hormone therapy represent an effective and well–tolerated treatment forlocally recurrent prostate cancer after radical prostatectomy resulting in good local control. Long–term prognosis in terms ofbiochemical control and disease–specific survival remains poor. |
