腋窝乳房外Paget病1例

患者男,83岁。左侧腋窝红斑伴瘙痒6年。多次按湿疹治疗,无效;3年前始皮损伴轻度疼痛,瘙痒明显,反复破溃不能愈合。近日来皮损增大明显,予手术切除。切除物组织病理示:表皮轻度角化过度,表皮全层可见单个或成巢的Paget细胞,真皮浅层较多淋巴细胞浸润;AB染色(+),PAS染色(-);免疫组化示:CK7,CK8/18,CEA和Ki67均(+);S100和HMB45均(-)。诊断:乳房外Paget病。

A Case of Extramammary Paget' s Disease on the Axillary

A 83-year-old male,complaining of itch,had been suffered with erythema on the axillary fossa for 6 years,repeatedly misdiagnosed as eczema and received the Symptomatic treatment,but the symptom did not get better. He felt a little pain and much itch on the erythema with the skin disunion 3 years ago. The extent of the erythema got bigger recently and he received resection at last. Histological examnation showed: Epidermis hyperkeratosis,single or a nest of Paget cells in the epidermis and part of eccrine ductal epithelium,multiple lymphocytic infiltration in the superficial layer of dermis; AB staining(+),PAS staining(-). Immunohistochemistry showed:CK7,CK8/18,CEA and Ki67(+),S100 and HMB45(-). Diagnosis:extramammary Paget’s disease.