| FK-506抑制大鼠角膜移植免疫排斥反应的研究 |
| |
| 引用本文： | Lü L,Zhang W,Sun X. FK-506抑制大鼠角膜移植免疫排斥反应的研究[J]. 中华眼科杂志, 1999, 0(1): 25-28 |
| |
| 作者姓名： | Lü L Zhang W Sun X |
| |
| 作者单位： | 首都医科大学附属北京同仁医院眼科,北京市眼科研究所 |
| |
| 摘 要： | 目的建立近交系大鼠穿透性角膜移植动物模型,观察结膜下注射ＦＫ５０６对角膜移植免疫排斥反应的抑制作用。方法将近交系Ｌｏｕ大鼠２８只作受体,１４只Ｆ３４４大鼠作供体,分为３组,术后结膜下分别按每公斤体重注射０．１ｍｇＦＫ５０６、３ｍｇＣｓＡ及生理盐水,共２周。对角膜植片进行临床观察,以混浊、水肿和新生血管３项指标作为临床评估标准。结果３组角膜植片的存活时间分别为（２２１±５１７）、（１８４±１４）及（１２１±２１３）天,三者间差异有显著性（Ｐ＜０．０１）。结论ＦＫ５０６能显著延长大鼠角膜植片的存活时间,是一种有效的新型免疫抑制剂。
|
| 关 键 词： | 大鼠 角膜移植 穿透性 FK－506 免疫排斥反应 |
Experimental studies on the effect of the immunosuppressant FK-506 on penetrating keratoplasty rejection model in rats |
| |
| Lü L,Zhang W,Sun X. Experimental studies on the effect of the immunosuppressant FK-506 on penetrating keratoplasty rejection model in rats[J]. Chinese Journal of Ophthalmology, 1999, 0(1): 25-28 |
| |
| Authors: | Lü L Zhang W Sun X |
| |
| Affiliation: | Department of Ophthalmology, Affiliated Tong Ren Hospital, Capital Medical University, Beijing 100730. |
| |
| Abstract: | OBJECTIVE: To study the immunosuppressive effects of FK-506 on allogeneic transplantation in a rat model. METHODS: Inbred strain Lou rats were used as recipients, and F344 rats were used as donors. Subconjunctival injection of FK-506 0.1 mg/kg and cyclosporine A (CsA) 3 mg/kg were administered respectively for 2 weeks, and the grafts were inspected by clinical evaluation. RESULTS: The group receiving FK-506 had a significant delay in allograft rejection with mean survival time (22.1 +/- 5.17) days vs. (18.4 +/- 1.4) days for the CsA group and (12.1 +/- 2.13) days for the control group (P < 0.01). CONCLUSION: It is indicated that FK-506 would be a useful drug to suppress corneal graft rejection. |
| |
| Keywords: | Rats Keratoplasty penetrating Graft vs host reaction FK 506 |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ |
