益肾祛毒胶囊治疗慢性肾功能衰竭的实验研究

目的：探讨益肾祛毒胶囊对实验性慢性肾有衰竭（简称慢性肾衰）大鼠的治疗作用机理。方法：用阳离子化牛血清白蛋白造成大鼠膜性肾病诱发慢性肾衰后，再用益肾祛毒胶囊大、小剂量灌胃治疗５周，以包醛氧化淀粉作阳性对照药。结果：益肾祛毒胶囊能显著降低大鼠２４ｈ尿蛋白、血清肌酐、尿素氮、血清循环免疫复合物（Ｐ〈０．０１，Ｐ〈０．０５），且肾系数变小（Ｐ〈０．０１），肾小球内有核细胞数减少（Ｐ〈０１．０１），肾小管内

Experimental Study on Treatment of Chronic Renal Failure with Yishen Qudu Capsule

Objective: To study the mechanism of action of Yishen Qudu capsule (YSQDC) in experimental rat model of chronic renal failure (CRF). Methods: Membranous nephropathy model was induced by cationized bovine serum albumin intravenous administration in rats for 7 weeks and developed to CRF. The model was then treated with YSQDC of large or small dose by gastrogavage for 5 weeks. Oxidated starch was used in the control group. Results: YSQDC could reduce proteinuria, serum creatinine, blood urea nitrogen, total cholesterol, triglyceride and serum circulating immune complex (P<0 01 or P<0 05), it also reduced the kidney coefficient, glomerular cells and tubular protein cast significantly (all P<0 01). The strength of immune fluorescence weakened remarkably (P<0 01). The pathological lesions improved significantly after treatment under light and electron microscopic examination. Conclusion: YSQDC could improve renal function significantly and inhibit the progression of CRF.