Sleep in bipolar patients |
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Authors: | Larriany M F Giglio Ana C Andreazza Mônica Andersen Keila M Ceresér Julio C Walz Laura Sterz Flávio Kapczinski |
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Institution: | 1. Bipolar Disorders Program-Centro de Pesquisas, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, 2350, 90035-003, Porto Alegre, RS, Brazil 2. Department of Biochemistry, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil 3. Department of Psichobiology, UNIFESP, Universidade Federal de S?o Paulo, S?o Paulo, SP, Brazil
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Abstract: | Background Sleep disturbance has been described in bipolar disorder (BPD). Specific complaints may include frequent nighttime awakenings,
poor quality of sleep, reduction in total sleep time, and nightmares. Most patients with BPD also report insomnia when in
depression, but a significant percentage of patients report hypersomnia symptoms with prolonged nighttime sleep, difficulty
in wakening, and excessive daytime sleepiness.
Objectives The present study aims to investigate whether bipolar patients with sleep disorders presented impairment in quality of life,
disability, and global function.
Methods One hundred ninety bipolar patients type-I diagnosed by application of Structured Clinician Interview for DSM-IV Disorders
(SCID), were distributed in two groups based on absence or presence of sleep disorders. Quality of life, disability, and global
dysfunction were evaluated using the Health Organization’s Quality of Life instrument (WHOQOL-Brief), the Sheehan Disability
Scale, and the Global Assessment of Functioning (GAF), respectively.
Results Sleep complaints have negative influence on general quality of life, observed by decreased scores in WHOQOL and GAF domains
and increased Sheehan scores, indicating the importance of maintenance of normal sleep in bipolar patients.
Conclusion Our results suggest that sleep complains impair quality of life and global function. Collectively, further studies are warranted
to investigate the impairment of sleep disturbance on others neurotrophic factors and neurochemical pathways. |
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Keywords: | Bipolar disorder Sleep Quality of life Insomnia Disability GAF |
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