General, free and thrombocytic serotonin in the blood plasma of patients with hemorrhagic fever with renal syndrome

The study determined the content of free, total and thrombocytic serotonin in 26 patients suffering from hemorrhagic fever with renal syndrome (HFRS) varying in stage. Oligoanuria and polyuria periods of the disease were associated with a 5.5-fold increase in the level of free serotonin whereas the level of blood platelet serotonin reduced two-fold and more. The convalescence period was characterized by rapid recovery of free serotonin values, thrombocytic serotonin being still insufficient. Peak values of total serotonin were noted in the polyuric period.