六味地黄丸对老年性高血压患者肾保护作用的临床研究

目的探讨六味地黄丸对老年性高血压患者肾保护作用.方法采用随机对照方法,将符合标准的136例患者分为治疗组70例和对照组66例,治疗组口服六味地黄丸,同时服用西拉普利,对照组单服西拉普利,观察8周.在治疗前后分别检测患者BUN、Cr、mALB等肾功能指标及ET、NO等指标.结果治疗组降压总有效率95.7%,对照组总有效率86.4%,两组有显著性差别（P＜0.05）,治疗组在降低SBP及DBP方面明显优于对照组（P＜0.05）,治疗组在降低BUN,Cr、mALB、ET水平和升高NO水平方而亦明显优于对照组（P＜0.05）.结论六味地黄丸具备良好的保护靶器官功能,从不同程度上延缓或逆转了老年性高血压患者的肾损害,对老年性高血压患者具有多重性肾保护作用

Protective Effects of Liuwei Dihuang Pill on the Kidney of Patients with Senile Hypertension

Objective: To study projective effects of Liuwei Dihuang pill on the kidney of patients with senile hypertension. Methods: By using random method, 136 patients who were meet to selection criteria were divided into two groups: treatment group (70 patients) and control group (66 patients). The Liuwei Dihuang pill accompanied with Cilazapril was orally administrated to the patients in treatment group, and Cilazapril to control group simply. The treatment course was 8 weeks. The indexes such as BUN, Cr, mALB, ET and NO were detected before and after treatment. Results: The effective rate of decreasing blood pressure of treatment group was 95.7%, which was higher than that of control group (86.4%)(P<0.05). Compared to control group, the indexes of SBP, DBP, BUN, Cr, mALB and ET in treatment group decreased obviously after treatment, and NO level increased significantly(P<0.05). Conclusion: The Liuwei Dihuang pill has better protective effect on target organ, which is effective to defer or reverse kidney injury of patients with senile hypertension. So Liuwei Dihuang pill posses multiple protection function to the kidney of patients with senile hypertension.