Correlations between the pharmacokinetics and dynamics of pharmacological effects of bromantane |
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Authors: | S. A. Sergeeva S. V. Krapivin A. S. Losev I. S. Morozov |
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Affiliation: | (1) Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow |
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Abstract: | It is shown that there is a mathematical correlation between an integral characteristic of activity of the organism (the capacity for work), electrophysiological indexes of functioning of the brain structures, and the concentration of a novel derivative of 2-aminoadamantane, bromantane, in the brain. The nature of the correlation between integral characteristics of the organism studied on different levels is found to change depending on the time elapsed from the administration of the preparation and on its concentration in the blood or target tissue. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N o 3 pp. 305–308, March, 1995 Presented by M. D. Mashkovskii, Member of the Russian Academy of Medical Sciences |
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Keywords: | bromantane EEG spectral analysis psychostimulators |
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