Correlations between the pharmacokinetics and dynamics of pharmacological effects of bromantane |
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| Authors: | S A Sergeeva S V Krapivin A S Losev I S Morozov |
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| Institution: | (1) Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow |
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| Abstract: | It is shown that there is a mathematical correlation between an integral characteristic of activity of the organism (the capacity
for work), electrophysiological indexes of functioning of the brain structures, and the concentration of a novel derivative
of 2-aminoadamantane, bromantane, in the brain. The nature of the correlation between integral characteristics of the organism
studied on different levels is found to change depending on the time elapsed from the administration of the preparation and
on its concentration in the blood or target tissue.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
3 pp. 305–308, March, 1995
Presented by M. D. Mashkovskii, Member of the Russian Academy of Medical Sciences |
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| Keywords: | bromantane EEG spectral analysis psychostimulators |
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