| 缝隙连接在前列腺素F2a诱导离体脑血管收缩中作用的研究 |
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| 引用本文： | 洪德全,洪涛,裘伟光.缝隙连接在前列腺素F2a诱导离体脑血管收缩中作用的研究[J].江西医学院学报,2009,49(5). |
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| 作者姓名： | 洪德全 洪涛 裘伟光 |
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| 作者单位： | 洪德全(南昌大学,研究生院医学部2006级,南昌,330006);洪涛(南昌大学,第一附属医院神经外科,南昌,330006);裘伟光(南昌大学,第三附属医院神经外科,南昌,330008) |
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| 摘 要： | 目的 探讨缝隙连接在前列腺素F2a诱导离体脑血管收缩中的作用及其变化.方法 提取新西兰大白兔基底动脉后,用血管环张力实验检测各缝隙连接对基底动脉张力变化的作用;用血管条孵育实验检测基底动脉舒缩与缝隙连接蛋白表达变化之间的相互关系.结果 PGF2a呈浓度依赖性地诱导离体基底动脉收缩,缝隙连接阻断剂可呈浓度依赖性地抑制PGF2a诱导的基底动脉收缩;PGF2a可后使基底动脉平滑肌细胞中Cx43蛋白表达上调,缝隙连接阻断剂可有效地抑制PGF2a诱导的Cx43蛋白表达上调.结论 缝隙连接参与PGF2a诱导离体兔脑基底动脉的变化;缝隙连接蛋白的表达与离体兔基底动脉收缩的变化有密切关系.
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| 关 键 词： | 缝隙连接 前列腺素F2a 缝隙连接蛋白43 基底动脉 离体 动物 实验 兔 |
The Effect of Gap Junction in Prostaglandin F2a-induced Cerebral Vasoconstriction in Vitro |
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| HONG De-quana,HONG Taob,QIU Wei-guangc.The Effect of Gap Junction in Prostaglandin F2a-induced Cerebral Vasoconstriction in Vitro[J].Acta Academiae Medicinae Jiangxi,2009,49(5). |
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| Authors: | HONG De-quana HONG Taob QIU Wei-guangc |
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| Institution: | HONG De-quana,HONG Taob,QIU Wei-guangc(a.2006 Grade of Medical Department of Graduate School,b.Department of Neurosurgery,the First Affiliated Hospital,Nanchang University,Nanchang 330006,China,c.Department of Neurosurgery,the third Affiliated Hospital,Nanchang 330008,China) |
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| Abstract: | Objective To investigate the effects of gap junctions in isolated cerebral vessel contraction induced by Prostaglandin F2a(PGF2a).Methods The basilar arteries were isolateded from the dissociative brain stems.The tensile changes in basilar arteries were measured to test the effects of gap junctions,and the correlation between Cx43 protein expression and cerebral vasoconstriction were analysed by western blotting.Results PGF2a induced concentration-dependent contraction of basilar arterial rings in vitro,and... |
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| Keywords: | gap junction PGF2a connexin 43 basilar artery vitro animals laboratory rabbit |
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