| 替米沙坦油水分配系数的测定及其意义 |
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| 引用本文： | 宋桂军 柳菡 冯芳 胡志强 邓桂凤 刘相. 替米沙坦油水分配系数的测定及其意义[J]. 药物分析杂志, 2007, 27(11): 1704-1706 |
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| 作者姓名： | 宋桂军 柳菡 冯芳 胡志强 邓桂凤 刘相 |
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| 作者单位： | 中国药科大学药物分析教研室 |
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| 基金项目： | 本文系中国药科大学“本科开放性试验”论文 |
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| 摘 要： | 目的:测定替米沙坦的油水分配系数,预测并解释其在人体内的吸收、分布、排泄情况。方法:以正辛醇-水为模拟系统,采用摇瓶法-紫外分光光度法,在232 nm 波长处测定分配平衡后油相中药物浓度,由此计算替米沙坦的油水分配系数。结果:在正辛醇-水体系中,pH=7.29时替米沙坦的油水分配系数 lgP=2.22。结论:应用摇瓶-紫外分光光度法,能够准确测定替米沙坦的油水分配系数,并由此推测其体内过程。
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| 关 键 词： | 替米沙坦 油水分配系数 体内过程 |
| 文章编号： | 0254-1793（2007）11-1704-03 |
Determination of the partition coefficient and its significance of telmisartan |
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| SNG Gui - jun, LIU Han, FENG Fang , HU Zhi - qiang, DENG Gui - feng, LIU Xiang. Determination of the partition coefficient and its significance of telmisartan[J]. Chinese Journal of Pharmaceutical Analysis, 2007, 27(11): 1704-1706 |
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| Authors: | SNG Gui - jun LIU Han FENG Fang HU Zhi - qiang DENG Gui - feng LIU Xiang |
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| Affiliation: | Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | Objective:To determine the partition coefficient of telmisartan for the prediction of its absorption,distri- bution and excretion.Methods:A shake flask-ultraviolet spectrophotometry method was established to determine n - octanol/water partition coefficient of telmisartan.Results:The lgP of telmisartan under pH 7.29 is 2.22.Conclu- sion:The shake flask -ultraviolet spectrophotometry method can be used to determine the partition coefficient of telmisartan accurately and help to predict its intracorporal process. |
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| Keywords: | telmisartan partition coefficient intracorporal process |
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