| 急性粒—单核细胞白血病及急性单核细胞白血病MLL基因重排的检测 |
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| 引用本文： | Ma Z,Dong D,Cao Q. 急性粒—单核细胞白血病及急性单核细胞白血病MLL基因重排的检测[J]. 中华肿瘤杂志, 1997, 19(2): 143-145 |
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| 作者姓名： | Ma Z Dong D Cao Q |
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| 作者单位： | 上海第二医科大学附属新华医院,上海第二医科大学附属瑞金医院上海血液学研究所 |
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| 基金项目： | 上海市自然科学资金会重点项目,上海血液学研究所胡应洲资金 |
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| 摘 要： | 了解ＭＬＬ基因重排在急性粒－单核细胞白血病（Ｍ４）及急性单核细胞白血病（Ｍ５）中的发生率及其特点。方法用Ｓｏｕｔｈｅｒｎ印迹法对１０例Ｍ４及２７例Ｍ５患者进行ＭＬＬ基因重排的检测。结果共发现５例Ｍ５患者伴有ＭＬＬ基因异常,此组患者发病年龄轻,发病时白细胞数高,肝脾肿大明显,易并发中枢神经系统白血病,完全缓解率低,平均生存期短。结论ＭＬＬ基因重排在Ｍ５中发生率高,且此基因异常是预后不佳的标志。
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| 关 键 词： | 白血病.单核细胞.急性 MLL基因 基因重排 |
Detection of MLL gene rearrangement in acute myelomonocytic and monocytic leukemia |
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| Ma Z,Dong D,Cao Q. Detection of MLL gene rearrangement in acute myelomonocytic and monocytic leukemia[J]. Chinese Journal of Oncology, 1997, 19(2): 143-145 |
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| Authors: | Ma Z Dong D Cao Q |
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| Affiliation: | Xin Hua Hospital, Shanghai Second Medical University. |
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| Abstract: | OBJECTIVE: To reveal the incidence of MLL gene rearrangement and its clinical, features in acute myelomonocytic leukemia (M4) and acute monocytic leukemia (M5). METHODS: 10 patients with M4 and 27 cases with M5 were studied with the Southern blot technique to detect MLL gene abnormalities. RESULTS: 5 M5 patients were found to have MLL rearrangement, and these patients were characterized clinically by: (1) Younger at onset, (2) a higher white blood cell count (often > 100 x 10(9)/L), (3) frequent extramedullary involvement with hepatosplenomegaly and central nervous system leukemia (CNSL), and (4) a lower remission rate with a short survival time. CONCLUSION: There is a high incidence of MLL rearrangement in M5, and this gene abnormality stands for a marker of poor prognosis. |
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| Keywords: | Leukemia monocytic acute MLL gene Gene rearrangement |
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