| ^153Sm—乙二胺四亚甲基膦酸对Walker256癌荷瘤大鼠骨侵袭骨溶解… |
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| 作者姓名： | Shi B Fu Z Lei XH |
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| 作者单位： | 中国医学科学院中国协和医科大学药物研究所药理一室 |
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| 摘 要： | 目的 研究＾１５３Ｓｍ－乙二胺四亚甲基膦酸（＾１５３Ｓｍ－ＥＤＴＭＰ）对荷瘤大鼠骨侵袭、骨溶解的抑制作用。方法 运用Ｘ线骨骼照片和胫骨病理切片,观察Ｗａｌｋｅｒ２５６癌大鼠模型的肿瘤骨侵袭和骨溶解情况。结果 荷瘤大鼠静脉注射＾１５３Ｓｍ－ＥＤＴＭＰ７４,１４８ＭＢｇ／ｋｇ后,遭受Ｗａｌｋｅｒ２５６癌侵袭及发生骨溶解的胫骨数减少近一半,３７ＭＢｇ／ｋｇ组对癌的骨侵袭和骨溶解仍有抑制作用。但各组大鼠的
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| 关 键 词： | 骨肿瘤 放射疗法 钐153 EDTMP |
Inhibitory effect of samarium-153-labeled ethylenediaminetetramethylene phosphonate (EDTMP) on bone invasion and osteolysis in Walker 256 carcinoma bearing rats |
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| Shi B,Fu Z,Lei XH.Inhibitory effect of samarium-153-labeled ethylenediaminetetramethylene phosphonate (EDTMP) on bone invasion and osteolysis in Walker 256 carcinoma bearing rats[J].Chinese Journal of Oncology,1997,19(6):423-426. |
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| Authors: | Shi B Fu Z Lei X H |
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| Institution: | Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing. |
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| Abstract: | OBJECTIVE: To investigate the inhibitory effect of samarium-153 EDTMP on bone invasion and osteolysis in Walker 256 carcinoma bearing rats. METHODS: Invasion and resorption of tibia by Walker 256 carcinoma in rats were evaluated by X-ray and histological examination. RESULTS: Intravenous administration of 153Sm-EDTMP at a dose of 74 or 148 MBq/kg, the rat numbers with tibia invasion and bone resorption were reduced by fifty percent. 153Sm-EDTMP at a dose of 37 MBq/kg still exhibited inhibitory effect on bone invasion and osteolysis as compared with the control group. However, there was no indication of change in the weight of primary tumor even at the highest dose utilized. CONCLUSION: Samarium-153 EDTMP can inhibit bone invasion and osteolysis by Walker 256 carcinoma in rats, but it has no effect on the growth of the transplanted tumor. Therefore, that the effect of 153Sm-EDTMP is due to a reduction in tumor growth leading to decreased bone invasion and osteolysis can be reasonably ruled out. |
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