乳腺乳头状瘤病及其癌变组织c—erbB—2及p53蛋白表达的免疫组…

目的 探讨ｃ－ｅｒｂＢ－２及Ｐ５３蛋白在服腺乳头状瘤病及其癌变过程不同发展阶段的表达水平及其对早期癌变的诊断价值。方法对腺头状瘤病及其癌变不同发展阶段手术标本存档蜡块１８４例进行ｃ－ｅｒｂＢ－２及Ｐ５３蛋白免疫组化检测。结论ｃ－ｅｒｂＢ－２蛋白表达对早期发现重度乳头状瘤病癌变具有重要参考价值。

Immunohistochemical study of c-erbB-2 and p53 protein in breast papillomatosis and its malignant transformation

OBJECTIVE: To evaluate the levels of c-erbB-2 and p53 protein in different stages of papillomatosis of breast and its malignant transformation and value for early diagnosis. METHODS: Levels of c-erbB-2 and p53 protein were detected by immunohistochemistry in 184 paraffin-embeded blocks. RESULTS: c-erbB-2 protein expression was seen in all stages of papillomatosis with different degrees of proliferation and in tissues undergone malignant transformation. The rate of overexpression increased with the degree of proliferation. The p53 protein expression was not found in papillomatosis with mild to severe proliferation. It was only overexpressed in 3.5% of carcinoma arising from papillomatosis, but increased to 25% when invasion occurred. CONCLUSION: c-erbB-2 assay may be helpful for detection of early malignant change of the highly proliferative papillomatosis, especially when histopathological evidence of malignancy is still lacking. p53 protein is of no significant diagnostic value in these lesions.