| 33例头颈部恶性肿瘤患者局部过继免疫治疗的疗效观察 |
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| 作者姓名： | Han D Zhu X Huang Z |
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| 作者单位： | 北京市耳鼻咽喉科研究所,北京同仁医院 |
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| 摘 要： | 目的评价ＩＬ－２／ＬＡＫ细胞局部过继免疫疗法在头颈部恶性肿瘤治疗中的疗效。方法对３３例头颈部恶性肿瘤患者进行局部过继免疫治疗,采用ＩＬ－２每日１０～２０万单位局部注射,共１０天;于ＩＬ－２治疗的第４～８天同时于局部注射ＬＡＫ细胞１．０×１０８～５．０×１０８／ｄ。结果完全缓解１例,部分缓解６例,好转２０例,稳定６例,治疗总缓解率２１．２％,总有效率８１．８％。治疗后１,２,３年生存率分别为９６．３％、８３．３％、和７５．０％。组织病理学检查证实免疫治疗后肿瘤局部大量ＣＤ３、ＣＤ４阳性Ｔ淋巴细胞浸润。治疗过程中未见严重的毒副作用。结论局部应用ＬＡＫ细胞与ＩＬ－２治疗头颈部恶性肿瘤疗效明显,方法安全。
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| 关 键 词： | 头颈部肿瘤 免疫疗法.过继 淋巴因子激活的杀伤细胞 白细胞介素-2 |
The observation on treatment effects of local adoptive immunotherapy in 33 cases with head and neck cancer |
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| Han D,Zhu X,Huang Z.The observation on treatment effects of local adoptive immunotherapy in 33 cases with head and neck cancer[J].Chinese Journal of Oncology,1997,19(6):454-456. |
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| Authors: | Han D Zhu X Huang Z |
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| Institution: | Beijing Institute of Otolaryngology. |
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| Abstract: | OBJECTIVE: To evaluate treatment effects of local adoptive immunotherapy in 33 cases with head and neck cancer. METHODS: IL-2 1 x 10(5)-2 x 10(5) U per day was injected into tumor for 10 days; during the 4th-8th day LAK cells 1.0 x 10(8)-5.0 x 10(8) per day were combined with IL-2 injection. Then we analysized clinical effect, immunopathology, side effects, etc. RESULTS: CR was seen in 1 case; PR in 6, MR in 20 cases, and SD in 6 cases. The one-, two- and three-year survival rate was 96.3%, 83.3% or 75.0% respectively. The results of histopathology showed that there were large amount of T lymphocytes (CD3+/4+) infiltrating in the tumor area after immunotherapy. No serious side effects were found during the course of the treatment. CONCLUSION: Local injection of IL-2/LAK can be used as immunotherapy for head and neck cancer. |
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| Keywords: | Head and neck neoplasms Immunotherapy adoptive LAK cells Interleukin 2 |
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