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Development of an Advanced Hyperspectral Imaging (HSI) System with Applications for Cancer Detection |
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| Authors: | Matthew E. Martin Musundi B. Wabuyele Kui Chen Paul Kasili Masoud Panjehpour Mary Phan Bergein Overholt Glenn Cunningham Dale Wilson Robert C. DeNovo Tuan Vo-Dinh |
| Affiliation: | (1) Center for Advanced Biomedical Phoronics, Life Sciences Division, Oak Ridge National Laboratory, Tennessee, North Carolina, 37831-6101;(2) Thompson Cancer Survival Center, 1915 White Avenue, Knoxville, Tennessee, 37916, North Carolina;(3) Mechanical Engineering Department, Tennessee Technological University, Cookeville, Tennessee, 38501, North Carolina;(4) Department of Small Animal Clinical Sciences, University of Tennessee Veterinary School, Knoxville, Tennessee, 37996, North Carolina;(5) Fitzpatrick Institute for Photonics, Duke University, Durham, North Carolina, 27708-0291;(6) Present Adress: Fitzpatrick Institute for Photonics, Duke University, Durham, North Carolina, 27708-0291 |
| Abstract: | An advanced hyper-spectral imaging (HSI) system has been developed having obvious applications for cancer detection. This HSI system is based on state-of-the-art liquid crystal tunable filter technology coupled to an endoscope. The goal of this unique HSI technology being developed is to obtain spatially resolved images of the slight differences in luminescent properties of malignant versus non-malignant tissues. In this report, the development of the instrument is discussed and the capability of the instrument is demonstrated by observing mouse carcinomas in-vivo. It is shown that the instrument successfully distinguishes between normal and malignant mouse skin. It is hoped that the results of this study will lead to advances in the optical diagnosis of cancer in humans. |
| Keywords: | Hyperspectral imaging (HSI) Fluorescence imaging, Biomedical optics Laser-induced fluorescence |
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