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Histone deacetylase 11: A novel epigenetic regulator of myeloid derived suppressor cell expansion and function

Authors:	Eva Sahakian John J Powers Jie Chen Susan L Deng Fengdong Cheng Allison Distler David M Woods Jennifer Rock-Klotz Andressa L Sodre Je-In Youn Karrune V Woan Alejandro Villagra Dmitry Gabrilovich Eduardo M Sotomayor Javier Pinilla-Ibarz

Institution:	1. Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States;2. Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, United States;3. The Wistar Institute, Philadelphia, PA, United States

Abstract:

Keywords:	MDSC myeloid derived suppressor cells IMC immature myeloid cells HDAC histone deacetylase eGFP enhanced green fluorescent protein APCs antigen presenting cells ROS reactive oxygen species NO nitric oxide GVHD graft vs host disease PBMC peripheral blood mononuclear cells BM bone marrow DAPI diamidino-2-phenylindole DCs dendritic cells EL4 murine lymphoma cell line Panco murine pancreatic adenocarcinoma cell line LPS lipopolysaccharide
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