A concise synthesis of pawhuskin A |
| |
Authors: | Neighbors Jeffrey D Buller Matthew J Boss Kelly D Wiemer David F |
| |
Institution: | Department of Chemistry, University of Iowa, Iowa City, Iowa 52242-1294, USA. |
| |
Abstract: | Pawhuskin A is an isoprenylated stilbene that was isolated from Dalea purpurea and reported to have affinity for the opioid receptor in vitro. It has been synthesized through a convergent sequence that joins a prenylated aldehyde with a geranylated phosphonate in a stereoselective Horner-Wadsworth-Emmons condensation to afford the target E olefin isomer. This synthesis confirms the structure assigned to the natural product and establishes a route that may be used to explore its biological activity and to prepare more active analogues. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|