| 紫杉醇白蛋白纳米粒抗肿瘤临床研究进展 |
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| 引用本文： | 蔡鑫君,徐颖颖,倪坚军. 紫杉醇白蛋白纳米粒抗肿瘤临床研究进展[J]. 中国临床药理学与治疗学, 2011, 16(6): 716-720 |
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| 作者姓名： | 蔡鑫君 徐颖颖 倪坚军 |
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| 作者单位： | 浙江省中西医结合医院药剂科,杭州310003,浙江 |
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| 摘 要： | 以白蛋白为载体的紫杉醇纳米粒在抗肿瘤方面发挥了重要作用。本文对紫杉醇白蛋白纳米粒体内药动学过程、纳米粒转运机制进行探讨,并就近几年来紫杉醇白蛋白纳米粒在乳腺癌、非小细胞肺癌及其他恶性肿瘤方面的临床研究作一综述,为临床应用提供借鉴。
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| 关 键 词： | 紫杉醇 白蛋白纳米粒 临床研究 |
Clinical research advancement of nanoparticle albumin-bound paclitaxel in anti-cancer treatment |
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| CAI Xin-jun,XU Ying-ying,NI Jian-jun. Clinical research advancement of nanoparticle albumin-bound paclitaxel in anti-cancer treatment[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(6): 716-720 |
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| Authors: | CAI Xin-jun XU Ying-ying NI Jian-jun |
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| Affiliation: | CAI Xin-jun,XU Ying-ying,NI Jian-junDepartment of Pharmacy,Integrated Chinese and Western Medicine Hospital of Zhejiang Province,Hangzhou 310003,Zhejiang,China |
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| Abstract: | Albumin is a vital drug carrier for nanoparticle paclitaxel in the anti-cancer treatment.This paper reviewed the pharmacokinetics and mechanism of nanoparticle transport of nanoparticle albumin-bound paclitaxel,and summarized the recent clinical trials of nanoparticle albumin-bound paclitaxel in breast cancer,non-small cell lung cancer,and other malignant treatment which could be a reference for its clinical use. |
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| Keywords: | Paclitaxel Nanoparticle albumin-bound Clinical trial |
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