| 脂微球前列腺素E1改变糖尿病周围神经病变患者神经传导速度随机对照试验的Meta分析 |
| |
| 引用本文： | 刘琳,霍墨菲,孙瑞华.脂微球前列腺素E1改变糖尿病周围神经病变患者神经传导速度随机对照试验的Meta分析[J].中国临床药理学与治疗学,2011,16(5):523-529. |
| |
| 作者姓名： | 刘琳 霍墨菲 孙瑞华 |
| |
| 作者单位： | 中日友好医院,北京,100029 |
| |
| 摘 要： | 目的:评价脂微球前列腺素E1治疗糖尿病周围神经病变(DPN)的疗效与安全性。方法:计算机检索OVID-LWW、CNKI和万方数据库,收集以脂微球前列腺素E1为干预措施治疗糖尿病周围神经病变的随机对照试验研究(RCT)。对纳入研究进行方法学质量评价,提取有效数据进行Meta分析。结果:共纳入11个RCT,共978例糖尿病周围神经病变患者。试验组为普通基础治疗加脂微球前列腺素E1,对照组为基础治疗或基础治疗加B族维生素。Meta分析结果显示,试验组在改善DPN患者的神经传导速度方面优于对照组。治疗后,正中神经运动神经传导速度(MCV)和腓总神经MCV的加权均数差(WMD)及其95%CI分别是4.39(2.86,5.91)和3.38(2.21,4.54)。正中神经感觉神经传导速度(SCV)敏感性分析的WMD及其95%CI为3.55(1.86,5.24)。结论:脂微球前列腺素E1对DPN患者的神经传导速度可能有改善作用。因纳入文献的试验方法学质量较低,仍需开展科学规范、高质量、大样本、长期随访的RCT。
|
| 关 键 词： | 脂微球前列腺素E1 糖尿病神经病变 Meta分析 |
Effects of Lipo-prostaglandin E_1 on diabetic peripheral neuropathy:A meta-analysis |
| |
| LIU Lin,HUO Mo-fei,SUN Rui-hua.Effects of Lipo-prostaglandin E_1 on diabetic peripheral neuropathy:A meta-analysis[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2011,16(5):523-529. |
| |
| Authors: | LIU Lin HUO Mo-fei SUN Rui-hua |
| |
| Institution: | LIU Lin,HUO Mo-fei,SUN Rui-huaBeijing University of Chinese Medicine,Scientific Department of China-Japan Friendship Hospital,Beijing 100029,China |
| |
| Abstract: | AIM: To evaluate the efficacy and safety of Lipo-prostaglandin E1 on treating diabetic peripheral neuropathy(DPN) Lipo-prostaglandin E1. METHODS: The electronic databases OVID-LWW,CNKI and Wanfang were searched to collect randomized controlled trials(RCT) by interventions of Lipo prostaglandin E1 for the treatment of DPN.The methodological quality of the trials were evaluated and the valid data for Meta-analysis were extracted.RESULTS:11 RCT and 978 patients were included.Test group was treated combined wit... |
| |
| Keywords: | Lipo-prostaglandin E1 Diabetic neuropathy Meta analysis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
