| 多发性肌炎和皮肌炎临床特点分析 |
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| 引用本文： | 宣丹,盛君,李志,毛桐俊,徐亮,陆进明. 多发性肌炎和皮肌炎临床特点分析[J]. 中国临床药理学与治疗学, 2011, 16(5): 558-562 |
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| 作者姓名： | 宣丹 盛君 李志 毛桐俊 徐亮 陆进明 |
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| 作者单位： | 皖南医学院附属弋矶山医院风湿免疫科,芜湖241001,安徽 |
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| 摘 要： | 目的:对比分析多发性肌炎(PM)和皮肌炎(DM)的临床特征,提高临床认识、改善预后。方法:收集2006年8月至2009年8月间住院的PM和DM患者共32例,对其年龄、住院时间、肌力、血清肌酸磷酸激酶(CPK)水平、红细胞沉降率(ESR)、C反应蛋白(CRP)和股四头肌MRI、肺高分辩率CT(HRCT)进行比较分析。结果:DM组和PM组患者在年龄、肱二头肌力、股四头肌力、住院时间、ESR、CRP方面差异均无统计学意义(P>0.05)。CPK水平PM组(3032±2973)U/L显著高于DM组(390±947)U/L,差异有统计学意义(P=0.015)。DM和PM患者颈肌受累、吞咽困难、声音嘶哑等方面,差异无统计学意义(P>0.05)。DM组间质性肺炎(ILD)的发生率显著高于PM组患者(P=0.021),且MRI上水肿信号的改变比PM患者明显。PM组对糖皮质激素疗效显著优于DM组(P=0.013)。4例死亡均为DM患者,3例死于间质性肺炎合并感染后呼吸衰竭,1例死于横纹肌溶解综合症致急性肾功能衰竭。结论:DM患者CPK水平不及PM患者高,但并发ILD较多,预后较PM差。
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| 关 键 词： | 多发性肌炎 皮肌炎 预后 |
Compare study of clinical features in polymyositis and dermatomyositis |
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| XUAN Dan,SHENG Jun,LI Zhi,MAO Tong-jun,XU Liang,LU Jin-ming. Compare study of clinical features in polymyositis and dermatomyositis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(5): 558-562 |
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| Authors: | XUAN Dan SHENG Jun LI Zhi MAO Tong-jun XU Liang LU Jin-ming |
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| Affiliation: | XUAN Dan,SHENG Jun,LI Zhi,MAO Tong-jun,XU Liang,LU Jin-mingDepartment of Rheumatology,Yijishan Hospital of Wannan Medical College,Wuhu 241000,Anhui,Chin |
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| Abstract: | AIM: To study the difference of clinical charactertics between polymyositis and dermatomyositis patients. METHODS: 11 cases of polymyositis and 21 cases of dermatomyositis were included in this study.Their muscle strength,serum creatine phosphokinase(CPK) levels,erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),hospitalization times,the quadriceps muscle MRI and high-resolution lung CT(HRCT) were compared.RESULTS:There were no statistic differences among muscle strength,ESR,CRP,hospitalization tim... |
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| Keywords: | Polymyositis Ermatomyositis Prognosis |
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