乳酸菌素治疗小儿急性腹泻的Meta分析

目的:评价乳酸菌素治疗小儿急性腹泻的作用。方法:通过计算机检索CENTRAL(theCochrane central register of controlledtrials)、Medline、EMBASE、中国期刊全文数据库(CNKI)、中国生物医学文献数据库系统(CBM)、万方数据库等,收集国内外发表的涉及乳酸菌素治疗小儿急性腹泻的随机对照研究(RCT)。研究人群为急性腹泻患儿;干预措施为口服乳酸菌素;对照组为安慰剂;结局指标为腹泻持续时间,并以标准化均数差(sandard mean differece,SMD)及相应的95%置信区间作为效应指标对结局进行比较。Q统计量的I2检验来检测各研究间的统计学异质性。双侧P<0.05认为各研究间存在明显的异质性。采用Egger检验对发表偏倚进行量化检测。应用统计软件Stata11.0进行数据分析。结果:纳入分析的文章有7篇,共945例患者,其中乳酸菌素组479例,对照组466例。Meta分析结果显示接受乳酸菌素治疗的患儿腹泻持续时间平均缩短1.24 d[SMD=-1.24,95%CI=(-2.21,-0.28),Z=2.54,P=0.01]。结论:乳酸菌素治疗小儿急性腹泻有一定临床疗效。

Meta-analysis of lactobacillus for children acute diarrhoea

AIM:To evaluate the effect of lactobacillus in treating children acute diarrhoea. METHODS: By searching CENTRAL(the Cochrane central register of controlledtrials),Medline,EMBSE,CBM,CNKI and WANFANG et al,we collected both domestic and overseas published randomized controled trials about the effect of lactobacillus in treating children acute diarrhoea.The study subjects were children suffering from acute diarrhoea;the intervention was the lactobacillus;the control was placebo;and the outcome was the duration...