微管不稳定蛋白Stathmin--肿瘤基因治疗新靶点

微管不稳定蛋白Stathmin在细胞周期的不同阶段对微运动力平衡的调节发挥重要作用。多种恶性肿瘤中Stathmin都有高水平表达，抑制其表达可以干扰恶性细胞的细胞分裂、Stathmin的过表达可干扰紫杉醇与微管的结合，但增加长春碱类药物与微管的结合能力，临床用药时应予考虑。另外．Stathmin为肿瘤基因治疗提供了一个分子新靶点，腺病毒介导抗stathmin核酶治疗联合察素药物治疗可能获得更强有力的抗增殖和抗肿瘤效应。

Microtubule-destabilizing protein stathmin-a new target for gene therapy of cancer

Stathmin is a novel member of microtubule-destabilizing proteins that play a critical role in the regulation of the dynamic equilibrium of ,ocrpubules during different phases of the cell cycle. The overexpression of stathmin was found in ,different type of cancer, Inbibition of stalhmin expression in malignant cells may interfere with their orderly progression through the cell cycle. Overexpression of stathmin can affect the action of antimicrotuble drugs by markedly decreasing binding of paelitaxel, and increasing hinding of Vinca alkaloids. In addition, stathmin provides an attractive molecular targel for cancer therapy,it may be possihle to comhine adenovirus-mediated anti-stathmin ribozyme therapy with a chemntherapeulic agent such as taxol to obtain a more potent antiproliferative and antitumor effect.