E—cad、CD44v6在肺癌中的表达及意义

目的研究E-cad、CD44v6在肺癌中的表达,探讨其与肺癌临床病理特征、淋巴结转移的关系.方法利用免疫组化S-P法检测65例肺癌、13例支气管黏膜不典型增生和8例正常肺组织的E-cad、CD44v6蛋白表达.结果肺癌组织的E-cad阳性率(46.2%)显著低于支气管黏膜不典型增生(84.5%)和正常肺组织(100%)(P＜0.05,P＜0.01);肺癌阳性率与淋巴结转移、临床分期呈负相关(P＜0.01,P＜0.05).在肺癌的阳性率(83.1%)显著高于不典型增生(38.5%)和正常肺组织(25%)(P＜0.01);CD44v6阳性表达与肺癌淋巴结转移、临床分期、病理分级呈正相关(P＜0.05).肺癌组织的E-cad阴性与CD44v6阳性表达有显著的相关性(P＜0.01).结论肺癌组织中的E-cad失表达、CD44v6高表达与肺癌的发生发展、淋巴结转移及预后有一定关系.

Significance of E-cadherin and CD44v6 expression in lung cancers

Objective To investigate the correlation of the expression of E cad and CD44v6 with the clinicopathologic characteristics in lung cancers. Methods S P immunohistochemical staining was performed in 65 cases of lung cancers, 13 atypical hyperplasia of the bronchus and 8 normal lung tissues. Results Positive staining of E cad protein in lung cancers was significantly lower than that in atypical hyperplasia of the bronchus ( P <0.05) and normal lung tissues ( P <0.01), which had a negative correlation with clinical stages ( P <0.01) and lymph node metastasis ( P <0.05). But the expression of CD44v6 in lung cancers was much higher than that in the atypical hyperplasia and normal lung tissues ( P <0.01), which had a significantly positive correlation with the clinical stages , pathological grade and lymph node metastasis ( P <0.05). There was a significant relationship between no expression of E cad and over expression of CD44v6 in lung cancers. Conclusion Loss of the expression of E cad and over expression of CD44v6 may have a correlation with their lymph node metastasis and prognosis, in which E cad and CD44v6 play an important role in tumorgenesis and development of lung cancer.