Nodular Fasciitis of the Oral Cavity with Partial Spontaneous Regression (Nodular Fasciitis) |
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Authors: | Marina Lara de Carli Karin Sá Fernandes Décio dos Santos Pinto Jr. Andrea Lusvarghi Witzel Marília Trierveiler Martins |
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Affiliation: | 1. Department of Stomatology, School of Dentistry, Universidade de S?o Paulo, S?o Paulo, Brazil 4. Disciplina de Patologia Bucal, Faculdade de Odontologia, Universidade de S?o Paulo, Av. Professor Lineu Prestes, 2227, S?o Paulo, SP, 05508-000, Brazil 2. Department of Stomatology, Oral Pathology, School of Dentistry, Universidade de S?o Paulo, S?o Paulo, Brazil 3. Department of Stomatology, Oral Medicine, School of Dentistry, Universidade de S?o Paulo, S?o Paulo, Brazil
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Abstract: | Nodular fasciitis is a lesion found in the subcutaneous fascia that micoscopically presents as a benign proliferation of fibroblasts and myofibroblasts, which may be mistaken for a sarcoma due to clinically rapid growth. Diagnosis is by histopathology and of the immunohistochemical profile. We describe a case of nodular fasciitis in the oral cavity that demonstrated partial spontaneous regression. The patient was a 32-year-old man with a buccal mucosal mass, which had grown rapidly for 45 days. On microscopic examination, the lesion displayed a well-delineated but not encapsulated proliferation of spindle cells, with a nodular growth pattern. Immunohistochemical analysis showed positivity of the spindle cells for the antibodies against smooth muscle actin and muscle-specific actin (HHF-35). Treatment of such lesions typically involves complete conservative excision, but the lesion may regress eventually in the absence of definitive treatment. |
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Keywords: | Nodular fasciitis Oral cavity Reactive lesion Spindle cells Spontaneous regression |
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