| 郁乐冲剂对抑郁症患者认知功能的影响研究 |
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| 引用本文： | 刘红敏,李晋芳,肖四飞.郁乐冲剂对抑郁症患者认知功能的影响研究[J].河南中医学院学报,2010(1). |
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| 作者姓名： | 刘红敏 李晋芳 肖四飞 |
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| 作者单位： | 深圳市中医院; |
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| 基金项目： | 深圳市科技计划项目(编号:200802122) |
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| 摘 要： | 目的:研究郁乐冲剂治疗抑郁症认知功能障碍的药理机制及临床疗效。方法:收集符合诊断标准的抑郁症患者60例,随机分为郁乐冲剂组、百忧解组2组,健康对照组选取深圳市中医院健康职工、在院研究生、实习生,共20名。疗程为84d。观察指标包括:治疗前后神经病理学测验方法l7项汉密顿抑郁量表(HAMD)、治疗前后神经心理学测验方法威斯康星卡片分类测验(WCST)、治疗前后血浆皮质醇浓度测定。结果:郁乐冲剂组有效率为89.66%,百忧解组为88.46%,两组相比无显著性差异(P>0.05);治疗后郁乐冲剂组与百忧解组患者HRSD总分及各因子分均下降,差异有统计学意义(P<0.05),在各因子分所代表的靶症状群改善上,郁乐冲剂与百忧解表现略有不同:其中焦虑/躯体化、睡眠障碍两个因子分两者改善程度接近(P>0.05),与健康对照组得分差异无统计学意义(P>0.05),认知障碍因子分和迟滞因子分改善上,两者改善程度接近(P>0.05),得分仍低于健康对照组,差异有统计学意义(P<0.05);治疗后郁乐冲剂组与百忧解组患者WCST因子分正确数、分类数提高,错误数、持续错误数、随即错误数均下降,差异有统计学意义(P<0.05),治疗后...
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| 关 键 词： | 抑郁症认知功能障碍 郁乐冲剂 疗效 |
The Effect of Yule Powder Preparation for Infusion on Cognition Ability of Depression Patient |
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| Liu Hongmin,Li Pufang,Xiao Sifei Shenzhen Municipal Hospital of Chinese Medicine,Shenzhen,Guangdong,China.The Effect of Yule Powder Preparation for Infusion on Cognition Ability of Depression Patient[J].Journal of Henan University of Chinese Medicine,2010(1). |
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| Authors: | Liu Hongmin Li Pufang Xiao Sifei Shenzhen Municipal Hospital of Chinese Medicine Shenzhen Guangdong China |
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| Institution: | Liu Hongmin,Li Pufang,Xiao Sifei Shenzhen Municipal Hospital of Chinese Medicine,Shenzhen,Guangdong,China 518033 |
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| Abstract: | Objective:To research pharmaco-mechanism and clinical curative effect of depression cognitive dysfunction treating with Yule medicinal instant granules.Methods:60 cases agreed diagnostic code were collected,were randomly divided into Yule group and Prozac group.Healthy employees,postgraduates and trainees(20 people) of Shenzhen Municipal Hospital of Chinese Medicine in heathy control groups,12 weeks is one course of treatment.Observation index include:Pretherapy and post-treatment neuropathology test method... |
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| Keywords: | depression cognitive dysfunction yule powder preparation for infusion curative effect |
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