Inflammatory peptide in spinal cord: evidence that the mediator of antidromic vasodilatation is not substance P |
| |
| Authors: | L A Chahl S W Manley |
| |
| Affiliation: | Department of Physiology, University of Queensland, St. Lucia, Queensland 4067 Australia |
| |
| Abstract: | Extracts from rat and bovine spinal cord were found to have 300-1000 times more cutaneous oedema-inducing activity than could be attributed to their substance P-like activity estimated by assay on guinea-pig ileum. The activity on both assay systems was reduced in cord extracts from rats pretreated as neonates with capsaicin. Results of assays of fractions obtained from gel-filtration chromatography indicated that an agent, in the molecular size range for peptides, was present in spinal cord extracts, which possessed some of the properties of substance P but was not identical to it. |
| |
| Keywords: | Present address for correspondence: Faculty of Medicine University of Newcastle Newcastle New South Wales 2308 Australia. |
| 本文献已被 ScienceDirect 等数据库收录！ |
