| 氨酚帕马溴片健康人体药动学 |
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| 引用本文： | 李见春,马涛,霍强,张俊东,董海军,高署,蒋志文. 氨酚帕马溴片健康人体药动学[J]. 中国医院药学杂志, 2010, 0(4) |
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| 作者姓名： | 李见春 马涛 霍强 张俊东 董海军 高署 蒋志文 |
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| 作者单位： | 蚌埠医学院药学系药剂教研室;合肥合源医药科技股份有限公司; |
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| 摘 要： | 目的:研究氨酚帕马溴片在健康人体单、多次给药的药动学。方法:30名健康女性志愿者,随机平均分为3组,单次给药分别口服氨酚帕马溴片1片(含对乙酰氨基酚500mg、帕马溴25mg)、2片、3片,单次给药采血结束,中剂量组继续给药,每次2片,q8h×6d。按试验方案采血,高效液相色谱法同时测定血清中对乙酰氨基酚和8-溴茶碱浓度,DAS2.0软件计算药动学参数。结果:健康受试者单次给药后各组对乙酰氨基酚的主要药动学参数tmax分别为(0.75±0.17),(1.2±0.7),(0.9±0.4)h;Cmax分别为(10.0±1.5),(22.4±6.9),(26.6±5.0)mg.L-1;MRT0-48h分别为(3.5±0.3),(3.5±0.8),(3.6±0.4)h;AUC0-48h分别为(37.5±4.2),(72.3±10.2),(105.8±16.0)mg.h.L-1;8-溴茶碱的主要药动学参数tmax分别为(0.78±0.14),(1.4±1.0),(0.90±0.27)h;Cmax分别为(2.5±0.4),(5.2±1.1),(6.2±0.6)mg.L-1;MRT0-48h分别为(12.0±2.7),(1...
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| 关 键 词： | 氨酚帕马溴 高效液相色谱 药动学 |
Investigation on the pharmacokinetics of compound acetaminophen and pamabrom tablets in female healthy volunteers |
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| LI Jian-chun,MA Tao,HUO Qiang,ZHANG Jun-dong,DONG Hai-jun,GAO Shu,JIANG Zhi-wen. Investigation on the pharmacokinetics of compound acetaminophen and pamabrom tablets in female healthy volunteers[J]. Chinese Journal of Hospital Pharmacy, 2010, 0(4) |
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| Authors: | LI Jian-chun MA Tao HUO Qiang ZHANG Jun-dong DONG Hai-jun GAO Shu JIANG Zhi-wen |
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| Affiliation: | LI Jian-chun1,MA Tao1,HUO Qiang1,ZHANG Jun-dong2,DONG Hai-jun2,GAO Shu2,JIANG Zhi-wen1 (1.Department of Pharmacy,Bengbu Medical College,Anhui Bengbu 233030,China,2.Hefei Con-source Medicine Technology Corporation,Anhui Hefei 230088,China) |
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| Abstract: | OBJECTIVE To investigate the pharmacokinetics of compound acetaminophen and pamabrom tablets with a single and multi-dose po administration in Chinese female healthy volunteers.METHODS 30 female healthy volunteers were randomly divided into three groups.Three groups were administrated with single dose of compound acetaminophen and pamabrom tablets one tablet(containing 500 mg acetaminophen and 25 mg pamabrom),two tablets and three tablets,respectively.The middle doses groups were administrated with the dose... |
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| Keywords: | compound acetaminophen and pamabrom HPLC pharmacokinetics |
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