| 氨氯地平联合替米沙坦治疗老年高血压合并早期肾损害的临床研究 |
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| 引用本文： | 赵菁,何飞,胡大一,黄振文,张菲斐,邱春光,卢文杰,刘瑞云. 氨氯地平联合替米沙坦治疗老年高血压合并早期肾损害的临床研究[J]. 临床荟萃, 2009, 24(1): 5-8 |
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| 作者姓名： | 赵菁 何飞 胡大一 黄振文 张菲斐 邱春光 卢文杰 刘瑞云 |
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| 作者单位： | 北京大学人民医院,心脏中心,北京,100044;郑州大学第一附属医院,心内科,河南,郑州,450052 |
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| 摘 要： | 目的观察氨氯地平联合替米沙坦治疗老年高血压合并早期肾损害的临床疗效。方法老年高血压合并尿微量白蛋白（MAU）阳性者104例，随机分为氨氯地平联合替米沙坦组（观察组）52例，氨氯地平组（对照组）52例。观察组给予口服氨氯地平联合替米沙坦片，对照组单纯给予氨氯地平。观察治疗后8周血压下降和MAU、血β2-微球蛋白（β2-MG）、尿β2-MG、尿N-乙酰-B-D氨基葡萄糖苷酶（NAGE）、血管紧张素U（Ang11）及肝、肾功能变化情况。结果两组治疗2周、4周、6周和8周，收缩压和舒张压均有下降的趋势（P〈0．01）。观察组MAu、血β2-MG、尿β2-MG、尿NAGE、血AngⅡ的减少较对照组更明显，分别为（67．2±35．2）mg／dVS（140．5±28．3）mg／d，（3．0±1．9）mg／dVS（3．3±1．3）mg／d，（151．4±1．2）mg／dVS（190．2±1．0）mg／d，（20．4±5．5）U／LVS（21．6±3．6）U／L，（54．1±24．1）ng／LVS（55．7±6．9）ng／L（P〈0．05）。肝功能（丙氨酸转氨酶，天冬氨酸转氨酶）、肾功能（肌酐）变化两组间差异无统计学意义。结论氨氯地平联合替米沙坦治疗老年高血压合并早期肾损害临床疗效优于单纯使用氨氯地平。
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| 关 键 词： | 高血压 氨氯地平 替米沙坦 老年人 |
Clinical investigation of amlodipine joint with telmisartan on old hypertensive patients with early kidney damage |
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| ZHAO Jing,HE Fei,HU Da-yi,HUANG Zhen-wen,ZHANG Fei-fei,QIU Chun-guang,LU Wen-jie,LIU Rui-yun. Clinical investigation of amlodipine joint with telmisartan on old hypertensive patients with early kidney damage[J]. Clinical Focus, 2009, 24(1): 5-8 |
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| Authors: | ZHAO Jing HE Fei HU Da-yi HUANG Zhen-wen ZHANG Fei-fei QIU Chun-guang LU Wen-jie LIU Rui-yun |
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| Affiliation: | ZHAO Jing,HE Fei,HU Da-yi,HUANG Zhen-wen,ZHANG Fei-fei,QIU Chunguang,LU Wen-jie,LIU Rui-yun Department of Cardiology,Renmin Hospital of Peking University,Beijing 100044,China |
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| Abstract: | Objective To observe the therapeutic effect of amlodipine jointed with telmisartan on old hypertensive patients with early kidney damage.Methods Olderly patients with hypertension and urinary albumin(MAU) positive 104 cases,were randomly divided into two groups,amlodipine jointed with telmisartan(observer group,52 cases) and amlodipine(control group,52 cases).The patients in observer group were given oral amlodipine sustained-release tablets jointing with telmisartan,while the patients in control group were... |
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| Keywords: | hypertension amlodipine telmisartan aged |
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