儿童青少年期骨肉瘤综合治疗与截肢疗效分析

目的 比较儿童青少年期骨肉瘤两种治疗方法的疗效.方法 选取本院骨肉瘤患者21例.男14例,女7例；平均年龄14.5岁.发生部位:肱骨上端、股骨近端、胫骨上端各1例,股骨干5例,股骨远端13例.骨肉瘤患者分为综合化疗保肢组(A组,13例)和单纯截肢或小规则化疗截肢组(B组,8例).评价两组患者复发转移率、3 a生存率及A组患者术后肢体功能情况.结果 21例均获随访.A组患儿复发或转移率为15.4％(2/13例),低于B组患儿62.5％(5/8例),差异有统计学意义(P＜0.05).A组3 a生存率为69.2％,B组为25.0％,两组比较差异有统计学意义(P＜0.05).采用Enneking肢体肌肉骨骼系统肿瘤外科治疗重建术后功能评价系统,A组术后患肢功能优3例,良5例,可3例,差2例,优良率为61.5％.结论 新辅助化疗联合保肢手术能降低复发转移率,提高患儿的生存率,不但可以保留肢体,且保留的肢体具有良好功能,是治疗儿童青少年期骨肉瘤的理想方法.

Therapeutic Analysis of Combined Treatment and Amputation Therapy for Osteosarcoma in Children and Adolescent Patients

Objective To evaluate the clinical effects of two methods in treatment of children and adolescent patients with extremity osteosarcoma. Methods Twenty-one patients with extremity osteosarcoma were treated in Xinxiang Central Hospital including 14 male and 7 female,with an average of 14.5 years old,among them,1 case of the osteosarcoma was in the proximal humerus,1 case in the proxinal femur,5 cases in the femur,1 case in the proxinal tibial and 13 cases in the distal femur.The patients were divided into the...