| 过敏性紫癜患儿血清白细胞介素-10、白细胞介素-13、白细胞介素-15与C反应蛋白水平变化的意义 |
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| 引用本文： | 姜晶,陆彪. 过敏性紫癜患儿血清白细胞介素-10、白细胞介素-13、白细胞介素-15与C反应蛋白水平变化的意义[J]. 实用儿科临床杂志, 2011, 26(21): 1639-1641 |
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| 作者姓名： | 姜晶 陆彪 |
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| 作者单位： | 1. 宁夏医科大学研究生院,银川,750004
2. 宁夏医科大学附属医院儿科,银川,750004 |
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| 基金项目： | 宁夏自然科学基金(NZ09108) |
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| 摘 要： | 目的 分析过敏性紫癜(HSP)患儿急性期与缓解期血清IL-10、IL-13、IL-15、CRP水平变化及各项指标间的相关性,探讨其临床意义.方法 选择2010年9月-2011年5月确诊为HSP的住院患儿40例作为HSP急性期组研究对象,40例患儿经正规治疗2周左右,在皮疹、腹痛、关节肿胀疼痛症状消失后作为缓解期组研究对象.采用EHSA双抗体夹心法检测HSP患儿急性期与缓解期血清IL-10、IL-13、IL-15水平,采用免疫速率散射比浊法检测CRP水平.选取门诊同期体检健康儿童20例作为健康对照组.应用SPSS17.0软件对数据进行统计学分析.结果 1.HSP患儿急性期血清IL-10、IL-13、IL-15和CRP的水平明显高于缓解期组和健康对照组(P＜0.01或＜0.05)；缓解期组血清仅IL-13水平显著高于健康对照组(P＜0.05),而IL-10、IL-15及CRP的水平与健康对照组比较差异均无统计学意义(Pa＞0.05)；2.HSP患儿急性期血清IL-10、IL-13、IL-15和CRP各项指标间均存在显著相关性.结论 HSP患儿存在IL-10、1L-13、IL-15及CRP的分泌紊乱,其参与了HSP的发病过程.其中IL-10和IL-13可能起到一定保护作用.
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| 关 键 词： | 过敏性紫癜 白细胞介素-10 白细胞介素-13 白细胞介素-15 C反应蛋白 儿童 |
Changes of Serum Levels of Interleukin-10,Interleukin-13,Interleukin-15 and C-Reactive Protein in Children with Henoch-Schonlein Purpura and Their Clinical Significance |
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| JIANG Jing , LU Biao. Changes of Serum Levels of Interleukin-10,Interleukin-13,Interleukin-15 and C-Reactive Protein in Children with Henoch-Schonlein Purpura and Their Clinical Significance[J]. Journal of Applied Clinical Pediatrics, 2011, 26(21): 1639-1641 |
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| Authors: | JIANG Jing LU Biao |
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| Affiliation: | JIANG Jing1,LU Biao2(1.Postgradute Education College,Ningxia Medical University,Yinchuan 750004,Ningxia Hui Autonomous Region,China,2.Department of Pe-diatrics,Affiliated Hospital of Ningxia Medical University,China) |
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| Abstract: | Objective To analyze the changes of serum levels of interleukin(IL)-10,IL-13,IL-15 and C-reactive protein(CRP) in acute phase and convalescence in children with Henoch-Schonlein purpura(HSP),discuss the correlation among these indicators and investigate their clinical significance. Methods Forty children with HSP hospitalized from Sep.2010 to May 2011 were selected as subjects of acute phase group.The other 40 children were used as subjects of convalescence group after treated with regular treatment for abo... |
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| Keywords: | Henoch-Schonlein purpura interleukin-10 interleukin-13 interleukin-15 C-reactive protein child |
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