| 不同抗癫药物治疗对癫患儿血脂的影响 |
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| 引用本文： | 翟琼香,陈前,郭予雄,王春,张宇昕,陈志红. 不同抗癫药物治疗对癫患儿血脂的影响[J]. 实用儿科临床杂志, 2011, 0(22): 1746-1748 |
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| 作者姓名： | 翟琼香 陈前 郭予雄 王春 张宇昕 陈志红 |
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| 作者单位： | 广东省医学科学院广东省人民医院儿科;南方医科大学研究生院; |
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| 基金项目： | 国家自然科学基金(81071046); 广东省科技计划项目(2010B031600159);广东省科技计划项目(2009B030801250) |
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| 摘 要： | 目的探讨癫患儿血脂水平的改变及应用抗癫药物对血脂水平的影响。方法采用酶测定法分别测定2009年1月-2011年1月在小儿癫专科门诊随访治疗的55例癫患儿(全面性发作30例,单纯局限性发作18例,不能分类的发作7例)和30例健康体检儿童(健康对照组)血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)水平,分析癫患儿在单药或联合用药至少0.5 a后与健康对照组比较血脂水平的变化。结果癫患儿服用抗癫药物后引起其血脂水平的改变,与健康对照组血脂水平相比,血清TG、LDL-C显著升高(Pa<0.01),HDL-C水平显著下降(P<0.01);丙戊酸钠(VPA)单药治疗的癫患儿与健康对照组相比,TG、LDL-C升高及HDL-C降低,其差异有统计学意义(Pa<0.05,0.01),而单用VPA与联合用药组之间及两个联合用药组间血脂水平改变的差异均无统计学意义(Pa>0.05);联合用药组与健康对照组比较,其改变幅度VPA>VPA+拉莫三嗪>VPA+左乙拉西坦,但差异均无统计学意义(Pa>0.05)。结论癫患儿服用抗癫药物后存在血脂水平的改变,以单用VPA的改变最大。
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| 关 键 词： | 血脂水平 癫 儿童 |
Effect of Different Anti-Epileptic Drugs on Serum Lipids in Children with Epilepsy |
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| ZHAI Qiong-xiang,CHEN Qian,,GUO Yu-xiong,WANG Chun,ZHANG Yu-xin,CHEN Zhi-hong. Effect of Different Anti-Epileptic Drugs on Serum Lipids in Children with Epilepsy[J]. Journal of Applied Clinical Pediatrics, 2011, 0(22): 1746-1748 |
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| Authors: | ZHAI Qiong-xiang CHEN Qian GUO Yu-xiong WANG Chun ZHANG Yu-xin CHEN Zhi-hong |
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| Affiliation: | ZHAI Qiong-xiang1,CHEN Qian1,2,GUO Yu-xiong1,WANG Chun1,ZHANG Yu-xin1,CHEN Zhi-hong1(1.Department of Pediatrics,Guangdong Academy of Medical Science,Guangdong General Hospital,Guangzhou 510080,Guangdong Pro-vince,China,2.Department of Postgraduate,Southern Medical University,Guangzhou 510515,Guangdong Province,China) |
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| Abstract: | Objective To investigate the changes of lipid levels in children with epilepsy and the influence of anti-epileptic drugs on monotherapy and polytherapy on lipid levels. Methods Fifty-five children with epilepsy who visited Pediatric Neurology Clinic of Guangdong General Hospital from Jan.2009 to Jan.2011 were enrolled,with 30 cases of generalized seizures,18 cases of simple partial seizures,7 cases of unclassified seizures.The concentrations of total cholesterol(TC),triglycerides(TG),high-density lipoprotei... |
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| Keywords: | lipid level epilepsy child |
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