| 肺表面活性剂──开塞肺的临床前毒理学研究 |
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| 引用本文： | 刘传合 董声焕. 肺表面活性剂──开塞肺的临床前毒理学研究[J]. 中国生化药物杂志, 1997, 18(1): 9-12 |
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| 作者姓名： | 刘传合 董声焕 |
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| 作者单位： | 首都儿科研究所!北京，100020 |
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| 摘 要： | 为确定牛肺表面活性剂（开塞肺）临床用药的安全性，在大鼠、家兔对开塞肺进行了局部刺激实验、急性毒性实验、长期毒性实验。结果表明开塞肺是一种较为安全的制剂，常规剂量气管内滴入不会有毒性作用，多次或大剂量气管内给药可导致肺脏轻微的可逆性改变，长期大剂量腹腔内注射对各脏器系统无明显影响。
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| 关 键 词： | 肺表面活性剂 毒理 大鼠 兔 |
Preclinical Study of Pulmonary Surfactant (Calsurf) Toxicology |
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| Liu Chuanhe, Dong Shenghuan, Lin Jiuzhi, Xu Hui, Wang Hong, Hu Shousheng. Preclinical Study of Pulmonary Surfactant (Calsurf) Toxicology[J]. Chinese Journal of Biochemical Pharmaceutics, 1997, 18(1): 9-12 |
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| Authors: | Liu Chuanhe Dong Shenghuan Lin Jiuzhi Xu Hui Wang Hong Hu Shousheng |
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| Affiliation: | Liu Chuanhe; Dong Shenghuan; Lin Jiuzhi; Xu Hui; Wang Hong; Hu Shousheng(Capital Institute of Pediatrics (Beijing 100020 |
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| Abstract: | Acute toxiology, chronic toxicology and local reaction of lung to adminstration of pulmonary surfactant (Calsurf) were tested in rats and rabbits. The result of this study indicated that there was no side effect when instilled intratracheally by routine clinical dose, but wken instilled intratracheally in large dose or by many times there were mild pathological alteration in animal lungs. If by ip in large dose and many times it doesn't have remarkable harmful effects on au systeins and organs. |
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| Keywords: | Pulmonary surfactant Toxicology Rats Rabbits |
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