| 三七粉碎度对复方丹参片皂苷类有效成分体外溶出的影响 |
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| 引用本文： | 林青,黄琳,肖晓丽,李楚源,王德勤.三七粉碎度对复方丹参片皂苷类有效成分体外溶出的影响[J].中成药,2007,29(5):697-700. |
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| 作者姓名： | 林青 黄琳 肖晓丽 李楚源 王德勤 |
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| 作者单位： | 广州白云山和记黄埔中药有限公司现代中药研究院,广东,广州,510515 |
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| 摘 要： | 目的:考察不同粉碎度三七药粉制备的复方丹参片中皂苷类成分体外溶出情况,选择适宜的三七药粉粉碎度。方法:以不同粉碎度的三七药粉制备复方丹参片样品,以三七皂苷R1、人参皂苷Rg1、人参皂苷Rb1含量为测定指标,以桨法测定药物的体外累积溶出度。结果:测定复方丹参片的体外溶出速率,超微粉碎的三七药粉制备片剂的体外溶出速率显著低于200目以下的三七药粉制备的片剂。结论:复方丹参片用三七药粉以80~200目为佳。
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| 关 键 词： | 三七 三七皂苷 人参皂苷 复方丹参片 溶出度 |
| 文章编号： | 1001-1528（2007）05-0697-03 |
| 修稿时间： | 2006-08-21 |
Degree of grinding of Panax notoginseng on the saponins solubilities of Compound Danshen Tablets |
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| LIN Qing,HUANG Lin,XIAO Xiao-li,LI Chu-yuan,WANG De-qin.Degree of grinding of Panax notoginseng on the saponins solubilities of Compound Danshen Tablets[J].Chinese Traditional Patent Medicine,2007,29(5):697-700. |
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| Authors: | LIN Qing HUANG Lin XIAO Xiao-li LI Chu-yuan WANG De-qin |
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| Institution: | Modern Chinese Medicine Institute, Hutchison Whampoa Guangzhou Baiyunshan Chinese Medicine Co. , Ltd. , Guangzhou 510515, China |
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| Abstract: | AIM: To optimize the pulverization of raw material of Compound Danshen Tablets. METHODS: The Compound Danshen Tablets were prepared with 5 sizes of Panax notoginseng powders which were ground by normal pulverizer or super fine pulverizer.The paddle method was used,and the cumulative dissolution percentage of notoginsenoside R1,and ginsenoside Rg1,and ginsenoside Rb1 were determined by HPLC. RESULTS: Compared with that degree of grinding of Panax notoginseng was not more than 200 meshes,there was a prominent decrease in dissoluing rate of saponins of Compound Danshen Tablets prepared by more than 300 meshes of Panax notoginseng powder. CONCLUSION: The optimum degree of grinding of Panax notoginseng which used to prepare Compound Danshen Tablets is in the range of 80-200 meshes. |
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| Keywords: | Panax notoginseng notoginsenoside ginsenoside Compound Danshen Tablets dissolution rate |
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