| CD4+CD25+调节性T细胞在哮喘发生发展中的作用研究进展 |
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| 引用本文： | 张倩,殷凯生.CD4+CD25+调节性T细胞在哮喘发生发展中的作用研究进展[J].国际呼吸杂志,2007,27(1):37-40. |
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| 作者姓名： | 张倩 殷凯生 |
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| 作者单位： | 210029,南京医科大学第一附属医院呼吸科 |
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| 基金项目： | 国家自然科学基金青年科学基金项目(30400191)，国家自然科学基金自由申请项目(30570797) |
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| 摘 要： | 支气管哮喘被普遍认为是因Th1／Th2失衡，由过度激活的Th2细胞介导的气道炎症性疾病。然而，Th1／Th2理论并不能充分阐明哮喘的发病机制。近几年来，越来越多的证据显示调节性T细胞在哮喘的发生发展中起到很重要的作用，CD4^＋CD25^＋调节性T细胞作为调节性T细胞的一种亚型成为目前研究的热点。本文就近来对CD4^＋CD25^＋调节性T细胞研究的进展及其与哮喘的关系作一综述。
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| 关 键 词： | 调节性T细胞 哮喘 Toll样受体 |
The role of CD4+CD25+ regulatory T cell in the pathogenesis of asthma |
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| ZHANG Qian,YIN Kai-sheng.The role of CD4+CD25+ regulatory T cell in the pathogenesis of asthma[J].International Journal of Respiration,2007,27(1):37-40. |
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| Authors: | ZHANG Qian YIN Kai-sheng |
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| Abstract: | It is generally considered that asthma is a disorder of airway inflammation which is mediated by Th2 excessively activated because of the imbalance of Th1/Th2 paradigm.However,the pathogenesis of asthma couldn't be interpreted with Th1/Th2 paradigm sufficiently.Recently,more and more evidence highlight the substantial role of regulatory T cell in the nosogenesis of asthma.As a subtype of regulatory T cell,CD4~+CD25~+ regulatory T cell is focused on and widely researched.This review will explore the relation between CD4~+CD25~+regulatory T cell and asthma,and the progress of study of CD4~+CD25~+ regulatory T cell. |
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| Keywords: | Regulatory T cell Asthma Toll like receptor |
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