| 1,1,2-三甲基-1H-苯并[e]吲哚的制备 |
| |
| 引用本文： | 李玉娟,王钝,柴慧芳. 1,1,2-三甲基-1H-苯并[e]吲哚的制备[J]. 沈阳药科大学学报, 2005, 22(5): 355-356 |
| |
| 作者姓名： | 李玉娟 王钝 柴慧芳 |
| |
| 作者单位： | 1. 哈药集团制药总厂,黑龙江,哈尔滨,150046
2. 沈阳药科大学,制药工程学院,辽宁,沈阳,110016 |
| |
| 摘 要： | 目的合成1,1,2-三甲基-1H-苯并[e]吲哚。方法由2-萘胺经重氮化反应、还原反应制得2-萘肼,再与甲基异丙基酮经费歇尔吲哚合成反应制得目标化合物。结果与结论经熔点测定及1H-NMR分析确证目标化合物结构,总收率为26.4%。
|
| 关 键 词： | 1,1,2-三甲基-1H-苯并[e]吲哚 2-萘肼 费歇尔吲哚合成 |
| 文章编号： | 1006-2858(2005)05-0355-02 |
| 收稿时间： | 2004-11-17 |
| 修稿时间： | 2004-11-17 |
Synthesis of 1, 1, 2-trimethyl-1H-benz[e]indole |
| |
| LI Yu-juan,WANG Dun,CHAI Hui-fang. Synthesis of 1, 1, 2-trimethyl-1H-benz[e]indole[J]. Journal of Shenyang Pharmaceutical University, 2005, 22(5): 355-356 |
| |
| Authors: | LI Yu-juan WANG Dun CHAI Hui-fang |
| |
| Abstract: | Objective To prepare 1,1,2-trimethyl-1H-benz[e]indole.Methods 2-naphthylhydrazine was prepared from 2-naphthylamine via diazotization and reduction reactions,followed by a Fischer indole synthesis with isopropyl methyl ketone to give 1,1,2-trimethyl-1H-benz[e]indole.Results and Conclusions The desired product was obtained in overall yield of 26.4%.Its structure was confirmed by melting point and (()~1H-NMR). |
| |
| Keywords: | 1 1 2-trimethyl-1H-benz[e]indole 2-naphthylhydrazine Fischer indole synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
