Inhibition of Rous sarcoma virus production by formycin |
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| Authors: | L Sarih B Agoutin O Lecoq D Weill P Jullien T Heyman |
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| Affiliation: | 1. Institut de Biochimie Cellulaire et Neurochimie du Centre National de la Recherche Scientifique, 1 rue Camille Saint-Satins, 33077 Bordeaux cedex, France;2. Institut Curie Biologie, Centre Universitaire, 91405 Orsay, France |
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| Abstract: | The effect of formycin, an adenosine analog, on the growth of chick embryo fibroblasts and on Rous sarcoma virus (RSV) production was studied. An adverse effect on cell proliferation was observed in the presence of 10 microM formycin. Treatment with 5 microM formycin for 24 hr reduced by a factor of about 1000 the yield of infections progeny whereas the cell growth remained unaltered. Moreover the few particles released in the presence of formycin showed a markedly decreased ability to synthesize viral cDNA. This impairment was shown to be related to a nonfunctional primer tRNA. |
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| Keywords: | Author to whom requests for reprints should be addressed. |
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