| 吲哚胺2,3-二氧化酶与免疫系统功能调节 |
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| 引用本文： | 付云峰,任永欣,杨以阜,左建平. 吲哚胺2,3-二氧化酶与免疫系统功能调节[J]. 中国药理学通报, 2006, 22(11): 1296-1299 |
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| 作者姓名： | 付云峰 任永欣 杨以阜 左建平 |
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| 作者单位： | 中国科学院上海药物研究所免疫药理学研究室,上海,201203 |
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| 基金项目： | 中国科学院知识创新工程项目;国家自然科学基金;上海市科委资助项目 |
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| 摘 要： | 免疫应答受多种因素影响和调节,从而维持机体内环境的稳定。巨噬细胞、树突状细胞等抗原提呈细胞表达的吲哚胺2,3-二氧化酶(Indoleam ine 2,3-d ioxygenase,IDO)清除局部微环境中的色氨酸,诱导T淋巴细胞的凋亡,通过调节性T细胞的作用抑制T细胞的克隆性增生,参于细胞免疫的调节;在机体维持正常的妊娠以及自身免疫性疾病、器官移植排斥反应、肿瘤等疾病的发生发展中起着重要作用。调控IDO的活性可能是寻找防治免疫相关性疾病药物的新途径。
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| 关 键 词： | 吲哚胺2,3-二氧化酶 色氨酸 细胞免疫 |
| 文章编号： | 1001-1978（2006）11-1296-04 |
| 收稿时间： | 2006-07-04 |
| 修稿时间： | 2006-09-20 |
Regulatory effect of indoleamine 2,3-dioxygenase on immune system |
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| FU Yun-feng,REN Yong-xin,YANG Yi-fu,ZUO Jian-ping. Regulatory effect of indoleamine 2,3-dioxygenase on immune system[J]. Chinese Pharmacological Bulletin, 2006, 22(11): 1296-1299 |
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| Authors: | FU Yun-feng REN Yong-xin YANG Yi-fu ZUO Jian-ping |
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| Affiliation: | Laboratory of lmmunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China |
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| Abstract: | The regulation of immune response is affected by several factors in order to maintain homeostasis.Indoleamine 2,3-dioxygenase(IDO) is a tryptophan-catabolizing enzyme expressed by different types of APC,including macrophages and dendritic cells.IDO activity leads to regulatory effects on T cells,which are mediated by tryptophan depletion in specific local tissue microenvironments,the production of proapoptotic metabolites,and inhibition of T-cell clone proliferation through regulatory T cells.IDO plays an important role in protecting the allogeneic fetus from rejection,the development of autoimmune diseases,allograft rejection,and cancer.So regulation of IDO activity may offer a novel drug-based strategy to treat immune-related diseases. |
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| Keywords: | indoleamine 2, 3-dioxygenase trypto-phan cell immune |
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